Assessing kidney injury mechanisms in sepsis patients using PET imaging

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate renal perfusion and inflammation in patients suffering from sepsis and acute kidney injury (AKI) using positron emission tomography (PET). It will involve 10 critically ill patients with sepsis and AKI, alongside 5 healthy volunteers for comparison. The study will utilize marked water for renal perfusion assessment and a novel PET tracer that binds to neutrophil elastase to measure inflammation in the kidneys. Additionally, a CT scan will be performed simultaneously to provide anatomical imaging, and plasma levels of inflammatory mediators will be analyzed.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Patients with sepsis and AKI

* \> 30 years
* At least AKI stage 1 according to KDIGO where the last plasma creatinine is measured within 24 hours of the examination

Healthy volunteers

* \> 30 years
* No previously known kidney disease
* Normal plasma creatinine value

Exclusion Criteria:

* Chronic renal failure (CKD stage \>3a) or dialysis
* Instability in vital functions that makes PET-CT examination unsuitable
* Claustrophobia or other reasons that make the patient unable to lie still during the examination.
* Pregnancy and breastfeeding

Where it's running

• Uppsala university hospital
  Uppsala, Sweden Recruiting

Study contacts

• Study coordinator: Miklos Lipcsey, MD, PhD
• Email: miklos.lipcsey@uu.se
• Phone: +46186110000

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.