Assessing IV fluids to prevent pancreatitis after ERCP
Official title: Association Between Peri-procedural Intravenous Hydration and Post- Endoscopic Retrograde Cholangiopancreatography Pancreatitis
Run by University of Calgary · NCT05211206 · Data updated 2026-11-12
This study is testing if giving patients the right amount of IV fluids before and after a procedure can help prevent pancreatitis after an ERCP.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 13000 (estimated) |
| Sponsor | University of Calgary Academic / other |
| Locations | 1 site (Calgary, Alberta) |
| Status | Recruiting |
| Started | January 10, 2022 |
| Main results expected | December 31, 2026 |
| Study ends | June 30, 2027 |
| Registry record updated | April 29, 2026 |
| Trial ID | NCT05211206 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18 years or older who are referred for ERCP and can provide informed consent.
✕Probably not a fit
Patients with contraindications to ERCP or those unable to provide informed consent will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study investigates the relationship between peri-procedural intravenous fluid administration and the risk of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. It aims to evaluate short-term aggressive hydration regimens that are practical for outpatient settings, focusing on fluid type, volume, and timing. By analyzing these factors, the study seeks to identify effective strategies to reduce the incidence of post-ERCP pancreatitis, which is a significant adverse event associated with the procedure.
Why it matters
Potential benefit: If successful, this study could lead to improved protocols for IV fluid administration that significantly reduce the risk of pancreatitis after ERCP, enhancing patient safety and outcomes.
How similar studies have gone: Previous studies have shown that aggressive hydration can reduce the risk of post-ERCP pancreatitis, but this study's specific approach to short-term hydration regimens is novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Subject referred for ERCP, regardless of indication; * Subject age 18 years or older; * Subject able to give informed consent to involvement be included. Exclusion Criteria: * Subject has a standard contraindication to ERCP; * Subject or surrogate unable or unwilling to provide informed consent; * Subject age \< 18 years.
Where it's running
-
Peter Lougheed Hospital
Calgary, Alberta, Canada Recruiting
Study contacts
- Principal investigator: Nauzer Forbes, MD MSc — University of Calgary
- Study coordinator: Nauzer Forbes, MD MSc
- Email: nauzer.forbes@ucalgary.ca
- Phone: 403-592-5089
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Biomechanical Factors During ERCP for Digestive Specialists
This study tests how ERCP practitioners experience biomechanical stress during the procedure to see if adjustments to equipment or setup can reduce strain.
-
Early versus late laparoscopic gallbladder removal after clearing common bile duct stones with ERCP
This trial will test whether having your gallbladder removed soon after ERCP or waiting longer gives better outcomes for people who had stones cleared from their common bile duct.
-
Indomethacin vs diclofenac to prevent pancreatitis after ERCP
This trial tests whether a single 100 mg rectal dose of indomethacin or diclofenac given before ERCP better prevents post-ERCP pancreatitis in adults with a native papilla.
-
Preventing oxygen drops during ERCP with nasal PAP or capnometry
We'll try whether using nasal positive airway pressure or capnometry with low-flow oxygen during sedated ERCP reduces oxygen drops in adults receiving nurse-administered sedation.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.