Assessing inflammation resolution in advanced gum disease treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the levels of pro-resolution mediators in patients with Stage III and IV periodontitis undergoing non-surgical periodontal therapy, comparing these levels to those in healthy individuals. Periodontitis is a chronic inflammatory disease that can lead to tooth loss and systemic health issues. The research aims to understand how pro-resolving lipid mediators influence inflammation resolution and tissue healing in the context of periodontal disease. By analyzing these mediators before and after treatment, the study seeks to provide insights into their therapeutic potential.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Inclusion criteria:

1. Adult patients above 18 years old.
2. Interdental CAL at site of greatest loss ≥5 mm or extending to middle third of the root.
3. Interdental CAL at site of greatest loss ≥8 mm or extending to apical third of the root.
4. Probing depth ≥6 mm.
5. Vertical bone loss ≥3 mm.
6. Tooth loss due to periodontitis of ≤4 teeth. (Periodontitis Stage III)
7. Tooth loss due to periodontitis of ≥5 teeth. (Periodontitis Stage IV)
8. Furcation involvement Class II or III Moderate ridge defect.

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Exclusion Criteria:

* 1\. Pregnancy or lactation. 2. Smoking more than 20 cigarettes. 3. Immuno-inflammatory conditions of the skin and oral mucosa 4. systemic conditions affecting bone turnover and periodontal health status (e.g. endocrine and connective tissue diseases, bisphosphonate antiresorptive therapy, gastrointestinal diseases related to nutrition and mineral metabolism) 5. Periodontal or orthodontic treatment at least 6 months before the start of the study 6. Use of anti-inflammatory and antimicrobial agents within 3 months before sampling

Inclusion criteria for healthy group:

1. Systemically healthy patients.
2. Patients with an age range between 16 to 80 years.
3. Patients have a minimum of 20 teeth.
4. Less than 10% bleeding sites with probing depths ≤3 mm.
5. absence of erythema, oedema.

Where it's running

• Faculty of Dentistry-Cairo University
  Manial, Cairo Governorate, Egypt Recruiting
• faculty of dentistry Cairo university
  Cairo, Egypt Recruiting

Study contacts

• Study coordinator: Husam Ghazi Alharbi, Master Degree
• Email: husam.ghazi@dentistry.cu.edu.eg
• Phone: +201222284055

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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  Recruiting Phase 3 Al-Mustansiriyah University · Baghdad, Bab Al-Moadham · NCT06882564

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.