Assessing HPV-related infections in women linked to throat cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate the incidence of high-risk HPV infections and related anogenital lesions in women diagnosed with HPV-positive oropharyngeal squamous cell carcinoma (OPSCC) and their female partners. It will compare these findings with historical data from routine well-woman exams. The study also seeks to assess the sexual health and well-being of participants, develop standardized education for patients, and measure satisfaction with the screening process. Participants will complete surveys, watch an educational video, and undergo standard cervical screenings.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* \* Female patients with diagnosed HPV(+)OPSCC seen at the Mayo Clinic, Rochester

  * Age ≥ 18
  * Female partners of Mayo Clinic patients with diagnosed HPV(+)OPSCC
  * Patient has given permission to give his/her blood/saliva sample for research testing
  * Ability to complete questionnaire(s) by themselves or with assistance

Exclusion Criteria:

* \* HPV(-) OPSCC

  * Unable to provide informed consent
  * Unwilling to attend screening visit at Mayo Clinic site, if indicated
  * Unwilling/unable to complete surveys electronically

Where it's running

• Mayo Clinic in Rochester
  Rochester, Minnesota, United States Recruiting

Study contacts

• Principal investigator: Kathryn M. Van Abel, M.D. — Mayo Clinic in Rochester

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Selective dose reduction of neck radiation in HPV-associated oropharyngeal cancer

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• Decitabine plus standard surgery, radiation, and chemotherapy for HPV-negative operable head and neck cancer

  This trial will test whether adding decitabine to standard surgery and radiation/chemotherapy helps people with HPV-negative head and neck cancers that can be removed by surgery.

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• Combining lovastatin and pembrolizumab for advanced head and neck cancer treatment

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• Intranasal WSK-IM05 vaccine plus tislelizumab before surgery for HPV‑positive oropharyngeal cancer

  This phase I trial will see if an intranasal WSK‑IM05 vaccine given with the PD‑1 drug tislelizumab before surgery helps people with resectable HPV‑positive oropharyngeal cancer.

  Recruiting Phase 1 West China Hospital · Chengdu, Sichuan · NCT07565740

• Lowering nodal and primary tumor radiation dose in HPV-positive oropharyngeal cancer

  This phase II study tests whether reducing radiation doses to regions without visible cancer, while keeping the main tumor dose the same, can treat HPV-positive OPSCC with fewer side effects.

  Recruiting Phase 2 University of Cincinnati · Cincinnati, Ohio · NCT07497607

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.