Assessing how healthy bone marrow plasma cells use glutamine
In Vivo Assessment of Glutamine Utilization by Bone Marrow Plasma Cells in Healthy Subjects Using Stable Isotope Resolved Metabolomics: A Pilot Study
This study is testing how healthy bone marrow cells use a substance called glutamine to see if it helps us understand their metabolism better.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Sponsor | Mayo Clinic Academic / other |
| Locations | 1 site (Rochester, Minnesota) |
| Trial ID | NCT03384108 on ClinicalTrials.gov |
What this trial studies
This pilot study aims to evaluate the feasibility of an in vivo method for assessing glutamine utilization in the TCA cycle of normal bone marrow plasma cells from healthy individuals. It will involve 20 healthy adult participants aged 18 to 60, divided into two groups: one undergoing ex vivo analysis and the other in vivo analysis. The study will utilize 5-13C-Glutamine and bone marrow aspiration to gather data on glutamine metabolism. The findings may provide insights into metabolic processes in healthy bone marrow cells.
Who should consider this trial
Good fit: Ideal candidates are healthy adults aged 18 to 60 who can provide written consent.
Not a fit: Patients with renal failure, active liver disease, or other specified exclusion criteria may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance our understanding of metabolic processes in healthy bone marrow, potentially informing future research on related conditions.
How similar studies have performed: While this approach is novel, similar metabolic assessments have shown promise in other contexts, indicating potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Ages 18-60 * Able to provide written consent Exclusion Criteria: * Renal Failure * Pregnancy * Active steroid use * Active liver Disease * Anemia (Hemoglobin \< 12.5 g/dL in men and \< 11.5 g/dL in women) * H/O alcohol use (average \> 2 drinks per day) * BMI \> 30
Where this trial is running
Rochester, Minnesota
- Mayo Clinic — Rochester, Minnesota, United States (Recruiting)
Study contacts
- Principal investigator: Wilson Gonsalves, MD — Mayo Clinic
- Study coordinator: Wilson Gonsalves
- Email: gonsalves.wilson@mayo.edu
- Phone: 5072842511
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.