Assessing heart health in COVID-19 survivors over 50

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective study aims to identify and improve functional capacity in survivors of COVID-19 who are over 50 years old. Participants will be randomized to a cardio-COVID disease management plan (CC-DMP) that includes VO2 testing and imaging to detect reduced functional capacity and subclinical left ventricular dysfunction. The program will also involve clinical reviews for optimal risk factor control and exercise interventions over a 24-month period. The study seeks to demonstrate the feasibility of this approach in reducing heart failure risk among COVID-19 survivors.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. History of COVID-19 infection
2. Live within a geographically accessible area for follow-up

Exclusion Criteria:

1. Valvular stenosis or regurgitation of \>moderate severity
2. History of previous heart failure (baseline New York Heart Association (NYHA) classification \>2)
3. Inability to acquire interpretable images (identified from baseline echo)
4. Contraindications to beta blockers or angiotensin-converting enzyme inhibitors
5. Oncologic (or other) life expectancy \<12 months or any other medical condition (including pregnancy) that results in the belief (deemed by the Chief Investigators) that it is not appropriate for the patient to participate in this trial
6. Already taking both angiotensin converting enzyme inhibitors/ angiotensin receptor blockers and beta blockers, or intolerance (or allergy) to both.
7. Mobility impairment that would impact participants' ability to perform exercise
8. Unable to provide written informed consent to participate in this study

Where it's running

• Baker Heart and Diabetes Institute
  Melbourne, Victoria, Australia Recruiting

Study contacts

• Principal investigator: Thomas H Marwick, MD,PhD,MPH — Baker Heart and Diabetes Institute
• Study coordinator: Joel Smith, MSc
• Email: joel.smith@baker.edu.au
• Phone: +61385321964

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.