Assessing heart function before and after lung surgery
Assessment of Right Ventricular Contractile Reserve Following Lung Resection by Dobutamine Stress Cardiac Magnetic Resonance: a Feasibility Study
This study is testing if a special heart scan can help understand how lung surgery affects heart function in patients before and after their operation.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 42 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Belfast Health and Social Care Trust Academic / other |
| Locations | 1 site (Belfast, Northern Ireland) |
| Trial ID | NCT06465277 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the feasibility of using dobutamine stress cardiovascular magnetic resonance (CMR) scanning to evaluate right ventricular contractile reserve (RVCreserve) in patients undergoing lung resection. The study hypothesizes that lung resection may lead to impaired RV function during exercise, which could affect patients' functional capacity. Additionally, it aims to explore the impact of one lung ventilation on RV injury through the analysis of cardiac biomarkers. Participants will undergo CMR scanning and biomarker sampling pre- and post-operatively to gather data on these effects.
Who should consider this trial
Good fit: Ideal candidates include patients aged over 16 who are scheduled for elective lobectomy lung resection, oesophagectomy with one lung ventilation, or gastrectomy.
Not a fit: Patients who are pregnant, have ongoing participation in conflicting research, or have certain cardiac conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve the understanding of heart function in patients undergoing lung surgery, potentially leading to better management and outcomes.
How similar studies have performed: While this approach is novel in the context of lung resection, similar studies using CMR for cardiac assessment have shown promising results in other surgical contexts.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria:
* 1\) Provision of informed consent 2) Age \>16 years 3) Planned elective
1. lobectomy lung resection or
2. oesophagectomy surgery with one lung ventilation or
3. gastrectomy
Exclusion Criteria:
1. Pregnancy
2. On-going participation in any investigational research which could undermine the scientific basis of the study
3. Atrial fibrillation at baseline
4. Any contraindication to
a. CMR, i. Cardiac pacemaker, artificial heart valve, neurostimulator, cochlear implant ii. Aneurysm clips iii. Metal injuries to the eye iv. Loose metal in a part of the body b. Dobutamine stress testing as per the Society for Cardiovascular Magnetic Resonance64 i. Severe systemic arterial hypertension (≥220/120 mmHg) ii. Unstable angina pectoris iii. Severe aortic valve stenosis (peak aortic valve gradient \>60mmHg or aortic valve area \< 1cm2) iv. Complex cardiac arrhythmias including uncontrolled atrial fibrillation v. Hypertrophic obstructive cardiomyopathy vi. Myocarditis, endocarditis, or pericarditis vii. Uncontrolled heart failure
5. Lung resection specific
1. Wedge, segmental or sub-lobar lung resection
2. Pneumonectomy
3. Isolated right middle lobectomy
\-
Where this trial is running
Belfast, Northern Ireland
- Belfast Health and Social Care Trust — Belfast, Northern Ireland, United Kingdom (Recruiting)
Study contacts
- Study coordinator: Adam Glass
- Email: a.glass@qub.ac.uk
- Phone: +442890976378
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.