Assessing healing patterns in dental microsurgery for persistent infections
A 2D and 3D Radiographic Assessment of the Healing Pattern Associated With Conventional and Piezoelectric Periradicular Endodontic Microsurgery
This study is testing which of two dental surgery techniques works better to help people with ongoing pain after root canal treatment heal from their infections.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 44 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | King Abdullah University Hospital Academic / other |
| Locations | 2 sites (Irbid and 1 other locations) |
| Trial ID | NCT06031792 on ClinicalTrials.gov |
What this trial studies
This study evaluates the healing patterns associated with two types of endodontic microsurgery: conventional and piezoelectric techniques. A total of 44 patients with persistent symptoms after root canal treatment will be randomly assigned to one of the two surgical approaches. Preoperative and postoperative imaging will be conducted using digital radiographs and cone beam computed tomography (CBCT) to assess healing outcomes. Additionally, histological analysis will be performed on excised root tips to examine bacterial presence and tissue reactions.
Who should consider this trial
Good fit: Ideal candidates are medically fit individuals aged 18-65 with periodontally healthy teeth that have undergone root canal treatment.
Not a fit: Patients with active systemic diseases, emotional distress, or those with teeth deemed non-restorable will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment outcomes for patients with persistent apical periodontitis.
How similar studies have performed: While there is limited evidence on the use of piezoelectric techniques in endodontics, similar studies have shown promising results with conventional microsurgery approaches.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Medically fit patients * Age (18-65 ) * Teeth that are periodontally healthy * Coronally sealed root canal treated teeth Exclusion Criteria: * Patients with an active systematic disease that may affect the short- and long-term outcomes or restrict surgical intervention * Emotionally distressed patients * Patients who had received analgesics or antibiotics prior to surgery will be postponed * Cases where orthograde endodontic treatment is feasible, will be retreated at the post-graduate clinics and not included in this study * Teeth with poor prognosis (e.g., non-restorable, vertical root fracture, short roots, non-strategic tooth, endo-perio lesion
Where this trial is running
Irbid and 1 other locations
- Jordan University of Science and Technology — Irbid, Jordan (Recruiting)
- Jordan University of Science and Technology — Irbid, Jordan (Recruiting)
Study contacts
- Study coordinator: Lama A Awawdeh, PhD
- Email: lawawdeh@hotmail.com
- Phone: +962795412954
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.