Assessing fuel metabolism and circadian rhythms in older adults through time-restricted eating
Assessment of Fuel Utilization and Circadian Rhythms in Overweight, Older Adults Following Time Restricted Eating - Phase 2 (FAR Phase 2)
This study is testing if time-restricted eating can improve metabolism and daily body rhythms in older adults who have trouble with mobility.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 15 (estimated) |
| Ages | 65 Years and up |
| Sex | All |
| Sponsor | University of Florida Academic / other |
| Locations | 1 site (Gainesville, Florida) |
| Trial ID | NCT05482711 on ClinicalTrials.gov |
What this trial studies
This study aims to develop non-invasive measures to evaluate changes in fuel metabolism and circadian rhythms in older adults following a time-restricted eating intervention. It focuses on understanding the relationship between mitochondrial function, fuel utilization, and circadian health, which are crucial for healthy aging. Participants will be older adults who experience difficulty with mobility and have specific health criteria. The study seeks to provide insights that could enhance future research on aging and metabolic health.
Who should consider this trial
Good fit: Ideal candidates are men and women aged 65 and older who have difficulty walking and are relatively sedentary.
Not a fit: Patients who are actively trying to lose weight or have certain medical conditions such as diabetes or heart issues may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved strategies for enhancing mitochondrial health and overall well-being in older adults.
How similar studies have performed: While the specific approach of this study is novel, related research has shown promise in understanding the impact of metabolic health on aging.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Consent to participate in the study * Men and women ≥ 65 years old * Self-reported difficulty walking ¼ mile or climbing a flight of stairs * Self-reported sedentariness (\<150 minutes structured exercise per week) * Walking speed \<1 m/sec on the 4 m walk test * Able to walk unassisted (cane allowed) * Have a body mass index between 25 - 40 kg/m2 (inclusive) * HbA1c \< 5.7 % Exclusion Criteria: * Fasting \>12 hours per day * Actively trying to lose weight by participating in formal weight loss program or significantly restricting calorie intake * Resting heart rate of \>120 beats per minute, systolic blood pressure \> 180 mmHg and/or diastolic blood pressure of \> 100 mmHg * Unstable angina, heart attack or stroke in the past 3 months * Continuous use of supplemental oxygen to manage a chronic pulmonary condition or heart failure * Rheumatoid arthritis, Parkinson's disease or currently on dialysis * Active treatment for cancer in the past year * Diabetes Mellitus * Known history of skin sensitivity or allergic reaction to adhesives * Taking medications that preclude fasting for 16 hours (e.g. must be taken with food at least 12 hours apart) * Any condition that in the opinion of the investigator would impair ability to participate in the trial
Where this trial is running
Gainesville, Florida
- University of Florida — Gainesville, Florida, United States (Recruiting)
Study contacts
- Principal investigator: Stephen Anton, Ph.D. — University of Florida
- Study coordinator: Stephen Anton, Ph.D.
- Email: santon@ufl.edu
- Phone: 352-273-7514
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.