Assessing esophageal motility and symptoms after surgery for GERD
Effect of Esophageal Contractile Reserve on Changes in Esophageal Motility and Symptoms After Anti-reflux Surgery in Patients With Gastroesophageal Reflux Disease
Shandong University · NCT05380791
This study is testing how the strength of esophageal contractions before surgery affects symptoms and movement in the esophagus after surgery for people with GERD.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 70 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Shandong University (other) |
| Locations | 1 site (Jinan, Shandong) |
| Trial ID | NCT05380791 on ClinicalTrials.gov |
What this trial studies
This observational study investigates how preoperative esophageal contractile reserve affects postoperative symptoms and motility in patients with gastroesophageal reflux disease (GERD). Using high-resolution esophageal manometry, the study aims to track changes in esophageal motility and symptoms following anti-reflux surgery. The focus is on patients diagnosed with ineffective esophageal motility, as this condition may influence surgical outcomes. The study will involve follow-up visits to monitor these changes over time.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 years old who are undergoing surgery for GERD and have been diagnosed with ineffective esophageal motility.
Not a fit: Patients with previous upper gastrointestinal surgery or specific esophageal motility disorders like nutcracker esophagus may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve surgical outcomes and symptom management for patients with GERD.
How similar studies have performed: While the specific approach of assessing preoperative esophageal reserve in relation to surgical outcomes is novel, high-resolution manometry has been successfully used in similar studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age over 18 years old * Patients to be treated surgically for gastroesophageal reflux disease * Ineffective esophageal motility diagnosed by high resolution esophageal manometry according to Chicago Classification version 4.0 * Obtaining Informed Consent Exclusion Criteria: * Previous other upper gastrointestinal surgery * Pregnant women and other people with contraindications to surgery and tests * Other specifically defined esophageal motility disorders, such as nutcracker esophagus
Where this trial is running
Jinan, Shandong
- Department of Gastroenterology, Qilu Hospital, Shandong University — Jinan, Shandong, China (RECRUITING)
Study contacts
- Study coordinator: FeiXue Chen, MD
- Email: qlxhkqz@163.com
- Phone: 18560086108
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Esophageal Motility Disorders, contraction reserve