Assessing Eosinophilic Esophagitis with a Swallowed String Test
Eosinophil Associated Proteins and Microbiome Profiling in Adults With Eosinophilic Oesophagitis at a Single UK Tertiary Centre
This study is testing a new, less invasive string test to see if it can help diagnose eosinophilic esophagitis in patients who usually need more invasive procedures.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 50 (estimated) |
| Ages | 18 Years to 90 Years |
| Sex | All |
| Sponsor | St George's, University of London Academic / other |
| Locations | 1 site (London) |
| Trial ID | NCT06159218 on ClinicalTrials.gov |
What this trial studies
This study focuses on evaluating a less invasive method for diagnosing eosinophilic esophagitis (EoE) using a coiled oesophageal string test. EoE is a chronic inflammatory condition of the esophagus that can lead to significant swallowing difficulties and other complications. Traditionally, diagnosis requires multiple biopsies through gastroscopy, which can be daunting for patients. The aim of this study is to determine if the string test can effectively detect biomarkers associated with EoE, potentially reducing the need for frequent invasive procedures.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 to 90 who have been diagnosed with eosinophilic esophagitis and are under the care of St George's University Hospital NHS Foundation Trust.
Not a fit: Patients under 18 or over 90 years old, those with significant medical co-morbidities, or individuals who have had complications from previous endoscopies may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could provide a less invasive and more patient-friendly method for diagnosing eosinophilic esophagitis.
How similar studies have performed: Previous studies have indicated that less invasive methods, such as the swallowed string test, may successfully detect biomarkers for eosinophilic esophagitis, suggesting potential for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient under the care of St George's University Hospital NHS Foundation Trust, London * Diagnosis of EoE as defined by endoscopy with mucosal biopsy showing \>15 eos/HPF * Male or Female * Age 18 to 90 Exclusion Criteria: * Patients \< 18 years old or \>90 years old * Patients with significant medical co-morbidities * Patients unable to provide consent for study participation * Patients who have had complications from their endoscopy or EoE treatment * Patients who have previously undergone oesophageal surgery
Where this trial is running
London
- St Georges University Hospitals NHS Foundation Trust — London, United Kingdom (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.