Assessing electrical properties of oral lesions
Official title: Characterizing In Vivo Oral Lesion Impedances
Run by Dartmouth-Hitchcock Medical Center · NCT05430477 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study is testing a special device to see if measuring the electrical properties of oral lesions can help doctors tell the difference between normal, benign, and cancerous growths in patients.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 260 (estimated) |
| Sponsor | Dartmouth-Hitchcock Medical Center Academic / other |
| Locations | 1 site (Lebanon, New Hampshire) |
| Trial ID | NCT05430477 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults aged 18 and older with suspected cancer in the oral cavity or related areas requiring biopsy or resection.
✕Probably not a fit
Patients who have had a previous oral biopsy within the last 30 days or those with implanted electrical devices may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to differentiate between normal, benign, premalignant, and malignant oral lesions by measuring their electrical impedance using a custom device. It involves two cohorts: one with patients undergoing oral lesion biopsies and another with patients scheduled for oral cancer resection. The study will collect data on electrical impedance and create a database of in vivo spectra and images of oral lesions. The device used is designed for high precision and accuracy in measuring impedance, complying with safety standards.
Why it matters
Potential benefit: If successful, this study could improve the diagnostic accuracy of oral lesions, aiding in early detection and treatment of oral cancers.
How similar studies have gone: While this approach is novel in its specific application to oral lesions, similar electrical impedance techniques have shown promise in other medical fields.
Who can join: the full rules
Show full inclusion / exclusion criteria
Cohort 1 10.1.1 Inclusion Criteria 1. Suspected cancer the oral cavity, oropharynx, hypopharynx, or larynx requiring biopsy. 2. Ability to understand and the willingness to sign a written informed consent document. 3. Age ≥ 18 years old. 4. If a female of child bearing potential, then a negative pregnancy evaluation per standard of care. 10.1.2 Exclusion Criteria 1. Adults having had a previous oral biopsy within the last 30 days 2. Adults with implanted electrical devices such as pacemakers 3. Prisoners 4. Adults with impaired decision-making capacity 5. Has any condition for which, in the opinion of the investigator, contraindicates study participation. Cohort 2 10.2.2 Inclusion Criteria 1. Clinical diagnosis or suspected cancer the oral cavity, oropharynx, hypopharynx, or larynx requiring resection. 2. Ability to understand and the willingness to sign a written informed consent document. 3. Age ≥ 18 years old 4. If a female of child bearing potential, then a negative pregnancy evaluation per standard of care. 10.2.3 Exclusion Criteria 1. Adults with implanted electrical devices such as pacemakers 2. Prisoners 3. Adults with impaired decision-making capacity 4. Any condition for which, in the opinion of the investigator, contraindicates study participation.
Where it's running
-
Dartmouth-Hitchcock Medical Center
Lebanon, New Hampshire, United States Recruiting
Study contacts
- Principal investigator: Ryan Halter, PhD — Trustees of Dartmouth College
- Study coordinator: Kathy Phipps, BA
- Email: kathy.j.phipps@dartmouth.edu
- Phone: 6036465793
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.