Assessing early physical therapy for jaw movement issues in head and neck cancer patients
Official title: Feasibility of PRospective Surveillance and Early PhysiCal Therapy for TrIsmuS in Individuals With Head and Neck CancEr: A Single-Group Feasibility Trial (PRECISE)
Run by University of Alberta · NCT06531083 · Data updated 2026-11-12
This study is testing if starting physical therapy early can help prevent jaw movement problems in head and neck cancer patients undergoing radiation treatment.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | University of Alberta Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Edmonton, Alberta) |
| Status | Recruiting |
| Started | March 1, 2025 |
| Main results expected | September 30, 2026 |
| Study ends | September 30, 2026 |
| Registry record updated | August 12, 2026 |
| Trial ID | NCT06531083 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals diagnosed with oral, oropharyngeal, or nasopharyngeal cancer who are scheduled for radiation therapy and reside in Alberta.
✕Probably not a fit
Patients with previous temporomandibular joint surgery unrelated to their cancer diagnosis or those with local cancer recurrence may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the feasibility of early physical therapy interventions to prevent trismus, a condition characterized by restricted jaw movement, in patients undergoing radiation therapy for head and neck cancer. A pilot study will involve 30 individuals who will receive weekly assessments and interventions, including manual therapy and exercise regimens, if they show a significant reduction in jaw opening. The study aims to gather data on recruitment, completion rates, and the acceptability of the intervention to inform future rehabilitation strategies for this patient population.
Why it matters
Potential benefit: If successful, this approach could significantly improve jaw mobility and quality of life for patients undergoing treatment for head and neck cancer.
How similar studies have gone: While there is limited research on early physical therapy for trismus, the approach of early intervention in similar conditions has shown promise, making this study both relevant and potentially impactful.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Have a diagnosis of oral, oropharyngeal, or nasopharyngeal cancer * Be scheduled to undergo cancer treatment that includes radiation therapy * Be able to read and understand English * Be an Alberta resident. Exclusion Criteria: * Previous surgery for the temporomandibular joint that is not related to the HNC diagnosis. * Local cancer recurrence or metastatic disease. * Unable to provide informed consent.
Where it's running
-
University of Alberta/ Cross Cancer Institute
Edmonton, Alberta, Canada Recruiting
Study contacts
- Principal investigator: Margaret McNeely, PhD — University of Alberta
- Study coordinator: Margaret McNeely, PhD
- Email: mmcneely@ualberta.ca
- Phone: 780-492-6007
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.