Assessing corneal properties in patients with pseudoexfoliation syndrome
A Comparative Study of Anterior Segment Structural Features, Biomechanical Behaviour and Optical Properties of the Cornea in Patients With and Without Pseudoexfoliation Syndrome.
This study is testing how pseudoexfoliation syndrome affects the eye's surface and structure in people aged 60-80 compared to others without the condition.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 86 (estimated) |
| Ages | 60 Years to 80 Years |
| Sex | All |
| Sponsor | Aristotle University Of Thessaloniki Academic / other |
| Locations | 1 site (Thessaloniki) |
| Trial ID | NCT06731530 on ClinicalTrials.gov |
What this trial studies
This observational study evaluates the impact of pseudoexfoliation syndrome on corneal biomechanics, optical clarity, and anterior segment structural features. Patients aged 60-80 with pseudoexfoliation syndrome will undergo a series of examinations using advanced imaging technologies, including Pentacam-AXL and Corvis ST, to assess corneal optical properties and biomechanical parameters. The results will be compared to a control group of age-matched individuals without the syndrome to better understand the effects of this condition on the eye.
Who should consider this trial
Good fit: Ideal candidates are individuals aged 60-80 with unilateral or bilateral pseudophakia and an open anterior chamber angle.
Not a fit: Patients with a history of intraocular surgery other than uncomplicated cataract surgery or those with significant ocular conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic and treatment strategies for patients with pseudoexfoliation syndrome.
How similar studies have performed: While there have been studies on corneal properties, this specific approach focusing on pseudoexfoliation syndrome is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * age 60-80 years. * unilateral or bilateral pseudophakia (cataract surgery undergone at Papageorgiou General Hospital, Thessaloniki, Greece). * open anterior chamber angle (grade \> 2, van Herick method). Exclusion Criteria: * History of intraocular surgery other than uncomplicated cataract surgery (phakoemulsification). * Cataract surgery within the last 3 months. * History of ocular trauma. * Use of contact lenses. * Corneal pathology. * Use of anti-VEGF medications. * History of uveitis or active uveitis. * Hypertension (IOP \> 21 mmHg) or glaucoma. * Myopia or hyperopia greater than 3 diopters. * Astigmatism greater than 1.5 diopters. * Posterior capsular opacification grade 2, 3, or 4 based on the EPCO grading scale. * Tear break-up time \<10 sec
Where this trial is running
Thessaloniki
- 2nd Department of Ophthalmology, Papageorgiou General Hospital — Thessaloniki, Greece (Recruiting)
Study contacts
- Study coordinator: Paraskevi Petridou, MD, MSc
- Email: evina_petridou@hotmail.com
- Phone: 00306985565799
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.