Assessing concussions using MRI and metabolomics
Official title: Correlating Advanced MRI Techniques With Neuropsychological Analysis and Immunosensing Assays for Assessment of Sport-related Mild Traumatic Brain Injuries (mTBI)
Run by St. Joseph's Healthcare Hamilton · NCT05993351 · Data updated 2026-11-12
This study is testing how MRI scans and body fluid samples can help us understand concussions better in people aged 9 to 50 who have recently had one.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 9 Years to 50 Years |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | St. Joseph's Healthcare Hamilton Academic / other |
| Locations | 1 site (Hamilton, Ontario) |
| Status | Recruiting |
| Started | August 11, 2023 |
| Main results expected | December 15, 2026 |
| Study ends | December 15, 2026 |
| Registry record updated | May 15, 2025 |
| Trial ID | NCT05993351 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are individuals aged 9-50 who have recently sustained a concussion within the last two weeks.
✕Probably not a fit
Patients who are outside the age range of 8 and younger or 51 and older, or those with contraindications for MRI, will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study focuses on understanding the effects of mild traumatic brain injuries (concussions) by utilizing advanced magnetic resonance imaging (MRI) techniques and symptom tracking. Participants aged 9-50 who have recently sustained a concussion will undergo MRI scans, provide urine and saliva samples, and complete questionnaires to monitor their symptoms over time. The goal is to correlate brain changes observed through imaging with reported symptoms to improve diagnosis and management of concussions, particularly in youth and collegiate athletes.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic methods and treatment strategies for individuals suffering from concussions.
How similar studies have gone: Other studies have shown promise in using advanced imaging techniques for concussion assessment, indicating that this approach is supported by prior research.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged between 9-50 * Recently sustained a concussion (within the last 2 weeks) Exclusion Criteria: * Aged 8 and younger or 51 and older * Unable to provide consent (e.g., poor English language skills, etc.) * History of liver or kidney disease * MRI contraindications: * Pacemaker * Stent * Joint prothesis * Implanted devices * Claustrophobia * Pregnant * Permanent piercings * Chronic/abusive use of alcohol and/or illicit drugs * Previous stroke or moderate/severe traumatic brain injury, subarachnoid hemorrhage, or intracranial hemorrhage * Healthy control participants must not have a concussion history or recently sustained a concussion
Where it's running
-
Imaging Research Center at St. Joseph's Healthcare Hamilton
Hamilton, Ontario, Canada Recruiting
Study contacts
- Principal investigator: Michael D Noseworthy, PhD, PEng — McMaster University
- Study coordinator: Michael D Noseworthy, PhD, PEng
- Email: nosewor@mcmaster.ca
- Phone: 905.525.9140
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.