Assessing cognitive function after carotid artery stenting

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the relationship between carotid artery disease and neurocognitive dysfunction by conducting a series of cognitive assessments and collecting serum markers of inflammation before and after carotid artery stenting. Patients with significant carotid stenosis will undergo cognitive testing at two points prior to the intervention and two points following it, allowing researchers to analyze changes in cognitive performance. Additionally, neuroimaging will be performed to assess brain blood flow and its correlation with cognitive outcomes. The study seeks to provide prospective evidence on how carotid stenosis impacts cognitive function and the potential role of inflammatory markers.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* patients \>18 years of age
* ultrasound evidence of carotid stenosis; in which the patient has either 50% or greater symptomatic carotid stenosis or 70% or greater asymptomatic carotid stenosis.

Exclusion Criteria:

1. patients \<18 years of age
2. patients with without compatibility for MRI
3. patients requiring carotid stenting for reasons not related to long-standing stenosis
4. patients requiring emergency carotid stenting for acute symptoms such as crescendo transient ischemic attacks, intolerance of physiologic blood pressure.
5. Patients that do not have appropriate capacity (i.e. understand the risks and benefits associated with this study) or are unable to consent for themselves will not be included in this study.

Where it's running

• UCSD Medical Center
  San Diego, California, United States Recruiting

Study contacts

• Principal investigator: Alexander A Khalessi, MD — UC San Diego
• Study coordinator: Alexander Khalessi, MD
• Email: akhalessi@ucsd.edu
• Phone: (619) 543-5540

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Carotid ultrasound to guide prevention of heart disease in inflammatory rheumatic diseases

  In people with inflammatory rheumatic diseases like RA, PsA, AxSpA, or SLE who are at modest cardiovascular risk, a carotid ultrasound test is used to see if they should start stronger lipid-lowering therapy to prevent heart problems.

  Recruiting at 7 sites Phase 4 Instituto de Investigación Marqués de Valdecilla · Alicante, Alicante and 16 other locations · NCT07611747

• Long-term follow-up of Intergard vascular grafts and patches

  This registry will see how Intergard grafts and patches perform and stay safe over time in adults who had bypass, repair, or replacement of the aorta, carotid, or peripheral arteries.

  Recruiting at 5 sites Intervascular · Hershey, Pennsylvania and 4 other locations · NCT07322913

• Mouth bacteria and carotid artery plaque vulnerability

  This project will see if mouth bacteria are linked to vulnerable carotid plaques in adults having carotid endarterectomy at Semmelweis University.

  Recruiting Semmelweis University Heart and Vascular Center · Budapest · NCT07296965

• SkyRunner carotid IVL before trans-carotid stenting for calcified carotid arteries

  This study tests the Shockwave SkyRunner carotid intravascular lithotripsy system to treat calcified carotid arteries before placing a trans-carotid stent in adults who are at high risk for traditional surgery.

  Recruiting at 17 sites Shockwave Medical, Inc. · Little Rock, Arkansas and 24 other locations · NCT07062471

• Evaluating a new system for protecting the brain during carotid artery procedures

  This study is testing a new device to see if it can help protect the brain during carotid artery procedures for people with narrowed arteries.

  Recruiting Shenzhen Wecan Medical Technology Co.,Ltd · Beijing · NCT06959628

• Monitoring blood flow during carotid surgery

  This study is testing a new way to manage blood flow during carotid surgery to see if it helps patients have better outcomes compared to standard treatment.

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Rome · NCT06926010

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.