Assessing cognitive and social skills in girls with Turner syndrome
Neuropsychological Assessment of Children and Adolescents With Turner Syndrome
This study is trying to understand the thinking and social skills of girls with Turner syndrome to see how they compare to girls with growth hormone deficiency.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 70 (estimated) |
| Ages | 7 Years to 16 Years |
| Sex | Female |
| Sponsor | University Hospital, Angers Government |
| Locations | 3 sites (Rennes, Ile Et Vilaine and 2 other locations) |
| Trial ID | NCT03812913 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate cognitive and socio-cognitive abilities in girls diagnosed with Turner syndrome compared to those with isolated growth hormone deficiency. The study will recruit 70 participants aged 7 to 16 years, with assessments conducted by neuropsychologists at specialized centers. Participants will undergo two visits, one at the clinic and another at home, to minimize disruption. The goal is to identify specific cognitive challenges that may contribute to social difficulties experienced by these young patients.
Who should consider this trial
Good fit: Ideal candidates are girls aged 7 to 16 years with a diagnosis of Turner syndrome or isolated growth hormone deficiency.
Not a fit: Patients with chronic conditions other than Turner syndrome or isolated growth hormone deficiency, or those with intellectual disabilities, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better understanding and support for the social and cognitive challenges faced by girls with Turner syndrome.
How similar studies have performed: While studies on cognitive functions in Turner syndrome exist, this specific approach of comparing it with isolated growth hormone deficiency is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
INCLUSION CRITERIA Turner syndrome group : * girls with diagnosed Turner syndrome. Isolated GHD group : * girls with diagnosed isolated growth hormone deficiency All participants : * age between 7 years to 16 years and 11 months. * informed consent signed by the participant and her parents (or her legal representatives) * being registered in the national social security system EXCLUSION CRITERIA : Turner syndrome group : * patients with chronic pathology other than Turner syndrome. * karyotype : part of a Y chromosome and r(X) cases. * medical treatment other than those usually prescribed in patients with Turner syndrome. Isolated GHD group : * patients with chronic pathology other than isolated growth hormone deficiency. * medical treatment other than those usually prescribed in patients with isolated growth hormone deficiency. All participants : * diagnosed intellectual disability (IQ\<70) or intellectual giftedness * history of acquired brain injury * sensory disturbances (auditory or visual) incompatible with the achievement of neuropsychological tasks. * insufficient French language proficiency
Where this trial is running
Rennes, Ile Et Vilaine and 2 other locations
- CHU Rennes — Rennes, Ile Et Vilaine, France (Recruiting)
- CHU Nantes — Nantes, Loire Atlantique, France (Recruiting)
- CHU Angers — Angers, Maine Et Loire, France (Recruiting)
Study contacts
- Principal investigator: Régis Coutant, MD PhD — UH Angers
- Study coordinator: Régis Coutant, MD PhD
- Email: ReCoutant@chu-angers.fr
- Phone: 33(02)41-35-56-55
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.