Assessing cognitive and neurophysiological outcomes after open heart surgery
Postoperative Clinical and Neurophysiological Assessment of Patients After Open Heart Surgery
This study looks at how open heart surgery affects thinking and brain function in patients, using special tests to see if their brain activity before surgery can predict how well they will think afterward.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 80 (estimated) |
| Ages | 60 Years and up |
| Sex | All |
| Sponsor | Ain Shams University Academic / other |
| Locations | 1 site (Cairo) |
| Trial ID | NCT06707454 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the clinical, cognitive, and neurophysiological outcomes of patients who have undergone open heart surgery, specifically focusing on those undergoing coronary artery bypass grafting (CABG). It utilizes digital electroencephalography (DEEG) to assess preoperative neurophysiological status and its correlation with postoperative cognitive function. The study aims to gather data from a sample of Egyptian patients to better understand the impact of cardiac surgery on cognitive health. The findings could help in predicting cognitive outcomes based on preoperative assessments.
Who should consider this trial
Good fit: Ideal candidates for this study are patients aged 60 and older scheduled for on-pump open heart surgery, either isolated CABG or combined CABG and valve surgery.
Not a fit: Patients with a history of central nervous system diseases, severe cognitive impairment, or those unable to undergo DEEG recordings may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance postoperative care by identifying patients at risk for cognitive decline after heart surgery.
How similar studies have performed: Other studies have shown success in using neurophysiological assessments to predict cognitive outcomes after cardiac surgery, indicating that this approach is supported by existing research.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient ≥ 60 years. * Both sexes. * Patients who are scheduled for on-pump open heart surgery either isolated coronary artery bypass grafting (CABG) or combined CABG and valve surgery. Exclusion Criteria: * Patients with a past history of CNS disease (e.g. Epilepsy, brain tumors, or Dementia). * Patients with metabolic disturbance. * Illiterate patient. * Patient with sever cognitive impairment on Mini-mental state Examination (MMSE) and/or Montreal Cognitive Assessment (MoCA) * Patients who cannot undergo DEEG recordings (eg, uncooperative). * Patients with abnormal brain images except for small vessel disease.
Where this trial is running
Cairo
- Ain Shams University — Cairo, Egypt (Recruiting)
Study contacts
- Study coordinator: Osama A Ebrahim, Master
- Email: osamaallam@med.asu.edu.eg
- Phone: 00201016386372
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.