Assessing cerebral blood flow response using a new index

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate the diagnostic performance of the Resistance Index (RI) in assessing cerebral vasoreactivity through transcranial Doppler ultrasound. The study seeks to identify patients with carotid stenosis or occlusion who may benefit from revascularization procedures by distinguishing those with normal vasoreactivity from those with altered responses. By simplifying the testing process, the goal is to reserve more complex assessments for patients who are likely to have abnormal vasoreactivity, thereby optimizing patient care and resource use.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* The patient must have given their free and informed consent and signed the consent form
* The patient must be a member or beneficiary of a health insurance plan
* Stenosis ≥ 70% in diameter reduction in NASCET equivalent or occlusion of atheromatous origin of the cervical internal carotid artery, asymptomatic or symptomatic.
* Presence of a temporal window sufficient to record the homolateral and contralateral middle cerebral artery.
* Patient of legal age with free and informed consent.
* Patient who has signed the consent form.
* Patient affiliated or beneficiary of a health insurance plan.

Exclusion Criteria:

* The subject is participating in an interventional study, or is in a period of exclusion determined by a previous study
* The subject refuses to sign the consent
* It is impossible to give the subject informed information
* The patient is under safeguard of justice or state guardianship
* Contraindication to Acetazolamide Diamox® injection.
* Absence of temporal acoustic window (non visualization of the cerebral parenchyma, no recordable intracranial vessel).
* Insufficient temporal window (visualizable brain parenchyma, no recordable MCA)
* Internal or common carotid artery stenosis ≥70% or occlusion, contralateral to the primary lesion.
* Stenosis ≥50% of the middle cerebral artery homolateral or contralateral to the cervical lesion.
* Patient in exclusion period determined by another study.
* Patient under court protection, guardianship, or conservatorship.
* Patient refusing to sign the consent form.
* Patient unable to express his or her will (dementia, disturbed consciousness, etc.)
* Patient for whom it is impossible to give informed information for health reasons or because of a language barrier.
* Pregnant, parturient, or breastfeeding patient.

Where it's running

• CHU de Nîmes
  Nîmes, France Recruiting

Study contacts

• Principal investigator: Sarah Coudray — CHU de Nimes
• Study coordinator: Sarah Coudray
• Email: sarah.coudray@chu-nimes.fr
• Phone: 04.66.6833.13

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.