Assessing Centhaquine for treating hypovolemic shock

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates the safety and efficacy of centhaquine citrate, a novel treatment for hypovolemic shock, in approximately 400 adult patients. Participants will receive centhaquine alongside standard shock treatment, including fluid resuscitation and vasopressors, while being closely monitored throughout their hospitalization. The study aims to determine if centhaquine can improve blood pressure, reduce lactate levels, and ultimately decrease mortality rates in these patients. The drug works by enhancing venous return to the heart and producing arterial dilation, which may improve cardiac output during resuscitation.

Why it matters

Who can join: the full rules

Inclusion Criteria

• Adult hypovolemic shock patients aged 18 years or older admitted to the emergency room or ICU with systolic blood pressure ≤ 90 mmHg at presentation and continue to receive standard shock treatment. Blood Lactate level indicative of hypovolemic shock (\>2.0 mmol/L).

Exclusion Criteria

* Development of any other terminal illness not associated with hypovolemic shock during the study duration.
* Patient with altered consciousness not due to hypovolemic shock and comatose patient. • Known pregnancy.
* Cardiopulmonary resuscitation (CPR) before enrollment.
* Presence of a do not resuscitate order.
* Patient is participating in another interventional study.
* Patients with systemic diseases which were already present before having trauma, such as sepsis, cancer, chronic renal failure, liver failure, decompensated heart failure, or AIDS.

Where it's running

• ACSR Government Medical College and Hospital
  Nellore, Andhra Pradesh, India Recruiting
• All India Institute of Medical Sciences (AIIMS)
  Raipur, Chhattisgarh, India Recruiting
• Aman Hospital
  Vadodara, Gujarat, India Recruiting
• New Era Hospital
  Nagpur, Maharashtra, India Recruiting
• Seven Star Hospital
  Nagpur, Maharashtra, India Recruiting
• Meditrina Hospital
  Nagpur, Maharashtra, India Recruiting

Study contacts

• Study coordinator: Dharmesh Shah, Dr.
• Email: dharmesh.shah@pharmazz.com
• Phone: +91(120)256-9779

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.