Assessing carotid plaque stiffness using ultrasound techniques

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate the accuracy of shear wave elastography (SWE) in measuring the stiffness of carotid atherosclerotic plaques and compare it with greyscale median values, MRI findings, and histopathological results. Participants will undergo vascular ultrasound to assess plaque stiffness and confirm stenosis through MRI. Those with significant stenosis may be considered for surgical intervention, and the removed plaques will be analyzed histopathologically. The study seeks to determine if plaque stiffness correlates with other imaging and pathological findings.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients with atherosclerotic carotid plaques that develop stenosis superior to 50%.

Exclusion Criteria:

* Previous cervical surgery;
* Previous cervical radiotherapy;
* Stenosis caused by vascular inflammatory diseases;
* Pregnant women;
* High carotid bifurcation (inaccessible by vascular ultrasound linear probe);
* Posterior acoustic shadowing that impair morphological evaluation of the plaque.

Where it's running

• Sao Paulo State University
  Botucatu, São Paulo, Brazil Recruiting

Study contacts

• Study coordinator: Pedro L Mellucci Filho, M.D.
• Email: p.mellucci@unesp.br
• Phone: +5518997378864

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.