Assessing cardiac autonomic nervous function using tilt tests
Composite Autonomic Scoring Scale and HUTT to Assess Cardiac Autonomic Nervous Function: A Preliminary Study
The First Hospital of Hebei Medical University · NCT06236945
This study is testing how well different heart function tests can help people with autonomic nervous system diseases understand their sympathetic and vagal nerve activity.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1122 (estimated) |
| Ages | 12 Years to 85 Years |
| Sex | All |
| Sponsor | The First Hospital of Hebei Medical University (other) |
| Locations | 1 site (Shijiazhuang, Hebei) |
| Trial ID | NCT06236945 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate cardiac autonomic nervous function in patients with autonomic nervous system diseases. It involves analyzing data from 169 patients who underwent a vertical tilt test and 24-hour Holter ECG monitoring. The study compares various indicators of autonomic function to identify the most reliable measures for assessing sympathetic and vagal nerve activity. By establishing sensitivity and specificity for these indicators, the research seeks to improve diagnostic capabilities for related conditions.
Who should consider this trial
Good fit: Ideal candidates for this study are patients who have undergone both a vertical tilt test and a 24-hour Holter ECG at the same time and are receiving treatment at the participating hospital.
Not a fit: Patients taking benzodiazepines or hypotensive drugs within 24 hours, or those with severe mental illness, dementia, or serious organ disease may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic tools for assessing cardiac autonomic function, potentially reducing the risk of serious cardiac events.
How similar studies have performed: While this approach is focused on a specific evaluation method, similar studies have shown promise in assessing autonomic nervous function, indicating potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria:
* Vertical tilt test and 24-hour holter electrocardiogram were performed at the same time
* Receive treatment in our hospital.
Exclusion Criteria:
* Taking benzodiazepines or hypotensive drugs within 24 hours
* Combined with mental illness, severe dementia, serious organ disease
* Severe arrhythmia, deep breathing and poor coordination of Valsaval movements affected the interpretation of results.
Where this trial is running
Shijiazhuang, Hebei
- The First Hospital Of Hebei Medical University — Shijiazhuang, Hebei, China (RECRUITING)
Study contacts
- Principal investigator: Yan Ding, M.D. — Department of Neurology，Xuanwu Hospital，Capital Medical University，Beijing，China.
- Study coordinator: Yan Ding, M.D.
- Email: dingding13001300@126.com
- Phone: 18633889260
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Autonomic Nervous System Diseases