Assessing brown fat activity in obese patients using semaglutide

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate the activity of brown adipose tissue (BAT) in obese individuals who are starting treatment with semaglutide, a GLP-1 agonist. Participants will undergo infrared thermography imaging to measure BAT activity at baseline, and again at 2-4 weeks and 18-20 weeks after starting the medication. The study hypothesizes that semaglutide will enhance BAT activity, leading to increased metabolic rates and weight loss. The findings could provide insights into the mechanisms of weight loss associated with GLP-1 agonists.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Subjects scheduled to start semaglutide for weight loss (drug not provided by or paid for by the study)
* \>18 years of age and willing to participate
* Male or post-menopausal females

Exclusion Criteria:

* History of prior neck surgery and /or neck irradiation

  * Use of beta blocker agents
  * Use of any other glucose lowering medication
  * History of neuropathic disorders (e.g. diabetic neuropathy)
  * Diabetic patients
  * Individuals without normal thyroid function
  * Individuals with cancer
  * Any significant chronic disease or renal, hepatic or endocrine disease
  * Current smokers
  * Inability of patient to provide consent either for medical reasons or psychiatric reasons

Where it's running

• UCLA Health
  Los Angeles, California, United States Recruiting

Study contacts

• Principal investigator: Preethi Srikanthan, MD — Principal Investigator
• Study coordinator: Preethi Srikanthan, MD
• Email: psrikanthan@mednet.ucla.edu
• Phone: 310-825-7922

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.