Assessing blood tests to predict risks in kidney disease patients with heart issues

Inclusion Criteria:

* Man or woman ≥18 years old and \<90
* If the subject is a woman, she must be on contraception or menopausal.
* Non-ST-segment elevation ACS defined by the presence of at least 2 of the following criteria: (1) symptoms of myocardial ischemia, (2) electrocardiographic ST-segment abnormalities (depression or transient elevation of at least 0.1 mV) or T-wave inversion in at least in 2 contiguous leads, or (3) an elevated cardiac troponin value (above the upper limit of normal) 56 or ST segment elevation ACS scheduled for primary PCI defined 57 as a history of chest discomfort or ischemic symptoms of \>20 minutes duration at rest ≤14 days prior to entry into the study with one of the following present on at least one ECG:

  1. ST-segment elevation ≥1 mm in two or more contiguous ECG leads
  2. New or presumably new left bundle branch block (LBBB).
  3. ST-segment depression ≥1 mm in two anterior precordial leads (V1 through V4) with clinical history and evidence suggestive of true posterior infarction
* Subject intended for an invasive strategy if NSTE-ACS or primary PCI if STE-ACS according to guidelines (appendix X)
* Subject with CKD stage 3A or higher (estimated glomerular filtration rate (eGFR) ≤ 60 ml/min/1.73 m2 according to the CKD-EPI formula
* Because of the documented biological variability of eGRF levels, patients with a eGRF \< 78 ml/min/1.73 m2 can be included in this study, based on previous blood test results and on the investigator's decision. The DFG level of 78 ml/min/1.73 m2 correspond to an increase of 30 % of a DFG of 60 ml/min/1.73 m2. Indeed, the literature estimated a DFG levels variability of 30 % 58-61.
* Must be enrolled at a cardiac catheterization laboratory hospital or at a hospital/ambulance service affiliated with a cardiac catheterization laboratory hospital.
* Subject affiliated to or beneficiary of a social security system.
* Subject having signed written informed consent.

Exclusion Criteria:

* \- Minors, pregnant or breast-feeding women;
* Subject under chronic anticoagulant
* Subject with thrombolytic therapy during the preceding 24 hours;
* Subject with bleeding diathesis;
* Subject not agreeing to participate.
* Subject with contraindication to clopidogrel, ticagrelor or to another anti platelet agent.
* Severe hepatic failure
* Ischemic Stroke within one month or a history of hemorrhagic stroke
* Platelet count\<100 000
* Major surgery or trauma within 10 days
* Life expectancy \<1 year
* Known significant bleeding risk according to the physician judgment
* Adults subject to a legal protection measure or unable to express their consent (persons under guardianship, curatorship or safeguard of justice)
* Persons deprived of their rights of liberty by judicial or administrative decision (persons in a situation of social fragility)
* Progressive cancer
* Systemic autoimmune disease
* Chronic viral or bacterial infections
* Diabetes requiring insulin therapy
* Constitutional haemorrhagic syndrome
* Organ transplantation