Assessing blood pressure medication effectiveness in patients with resistant hypertension
Clinical One-stage Controlled Study of reSistant Arterial Hypertension for the desiGning of a personAlized Approach to Therapy
This study tests how well blood pressure medications work in people with stubborn high blood pressure by checking the levels of the drugs in their blood.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 190 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Ryazan State Medical University Academic / other |
| Locations | 1 site (Ryazan) |
| Trial ID | NCT05899920 on ClinicalTrials.gov |
What this trial studies
This study aims to evaluate the concentration of antihypertensive drugs in the blood plasma of patients with both controlled and uncontrolled arterial hypertension. Participants will be randomized into two groups based on their blood pressure control status after 24-hour monitoring. Blood samples will be collected before and after medication intake to analyze the levels of specific antihypertensive drugs. The goal is to compare drug concentrations between the two groups to inform personalized treatment approaches.
Who should consider this trial
Good fit: Ideal candidates are adults diagnosed with arterial hypertension who are compliant with lifestyle modifications and are taking a combination of specific antihypertensive medications.
Not a fit: Patients who are pregnant or have a direct connection to the study organization will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more effective personalized treatment strategies for patients with resistant arterial hypertension.
How similar studies have performed: While similar studies have explored antihypertensive drug concentrations, this specific approach to personalized therapy in resistant hypertension is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Signed informed consent form; * An established diagnosis of AH based on the Clinical Guidelines "Arterial hyperten-sion in adults", approved by the Scientific and Practical Council of the Ministry of Health of the Russian Federation, 2020; * Mandatory patient compliance with recommendations for lifestyle modification in accordance with the Clinical Guidelines "Arterial hypertension in adults", approved by the Scientific and Practical Council of the Ministry of Health of the Russian Federation, 2020 . * Regular administration of any two antihypertensive drugs (lisinopril, amlodipine, valsartan) in combination with indapamide for a month, possibly in fixed combinations, in stable dosages; * Fertile female patients must use proper methods of contraception throughout the study period. Exclusion Criteria: * Patient's connection with the organization or conducting of the study; * Pregnancy.
Where this trial is running
Ryazan
- Ryzan State Medical University — Ryazan, Russian Federation (Recruiting)
Study contacts
- Study coordinator: Sergey V Seleznev, MD, PhD
- Email: sv.seleznev@gmail.com
- Phone: +79105749526
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.