Aquatic mobility test for infants with SMA

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter French project will compare infant mobility in standardized dry and in-water conditions using a 'bath test' protocol combined with wearable inertial sensors to detect subtle movements. Infants with genetically confirmed SMA type 1 will be recorded during routine follow-up visits at three pediatric neurology centers coordinated by Raymond Poincaré Hospital. The protocol aims to standardize recording conditions, quantify water-assisted movements, and track changes over time or after therapies. Parental consent is required and common exclusions include spinal cord lesions and significant cardiorespiratory disease.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Infants with muscle weakness (commonly referred to as floppy babies):

  * Confirmed diagnosis of SMA through gene mutation or deletion (SMN1 gene).
  * Receiving standard care.
  * Age less than 12 years and a height of less than 90 cm at the time of inclusion.
* Patients enrolled in a social security scheme.
* Informed consent signed by both parents of the child and the investigator.

Exclusion Criteria:

* Patients presenting with lesions in the spinal cord or conditions affecting the cardiorespiratory system.
* Patients covered under the French Aid in Health for Foreign People program (AME).

Where it's running

• Infantile neuromuscular unity - Department of paediatric neurological care and intentive care unity, Raymond Poincaré Hospital - APHP
  Garches, France Recruiting

Study contacts

• Principal investigator: Susana Quijano-Roy, MD, PhD — Paediatric neurological and intentive care unity, Raymond Poincaré Hospital - APHP
• Study coordinator: Susana Quijano-Roy, MD, PhD
• Email: susana.quijano-roy@aphp.fr
• Phone: + 33 1 47 10 78 90

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.