Aortic no-touch versus partial aortic clamping for off-pump coronary bypass

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter randomized controlled trial in China compares an aortic no-touch bypass technique (using RIMA-SVG) with conventional off-pump CABG that uses partial ascending aortic clamping (Ao-SVG). Adult patients with multivessel coronary artery disease scheduled for isolated off-pump CABG are randomized to one of the two surgical strategies and monitored for perioperative silent brain infarctions using neuroimaging and neurocognitive testing. Key exclusions include prior cardiac surgery, need for on-pump surgery, unsuitable graft conduits, severe aortic calcification, and contraindications to MRI. The trial aims to identify which revascularization approach better reduces perioperative cerebral ischemia and related morbidity.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients (\>18 years old) with multivessel coronary artery disease who are scheduled to undergo isolated off-pump coronary artery bypass grafting and who provide informed consent to participate in this study.

Exclusion Criteria:

* Indications for cardiopulmonary bypass surgery (or no contraindications to on-pump surgery);
* Great saphenous vein is unsuitable for use as a graft conduit;
* Subclavian artery stenosis or occlusion, or any contraindication to the use of the internal mammary artery as a graft conduit;
* History of previous cardiac surgery;
* Emergency surgery;
* Inability to apply an aortic clamp due to severe ascending aortic calcification;
* Expected inability to tolerate MRI or contraindications to MRI (e.g., known intolerance to MRI, an implanted permanent pacemaker, or an anticipated need for permanent pacemaker implantation);
* Inability to complete neurocognitive assessment due to language barriers or visual/hearing impairment.

Where it's running

• Fuwai Hospital Chinese Academy of Medical Sciences
  Beijing, China Recruiting
• Peking University First Hospita
  Beijing, China Not yet recruiting
• Qingdao Cardiovascular Hospital
  Qingdao, China Not yet recruiting
• Fuwai Hospital Chinese Academy of Medical Sciences, Shenzhen
  Shenzhen, China Not yet recruiting

Study contacts

• Study coordinator: Lianxin Chen
• Email: chenlianx1@163.com
• Phone: 01088322265

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.