Antioxidant moisturizing serum for mild to moderate seborrheic dermatitis on the face
A Prospective, Randomized, Split-Face Pilot Study Comparing the Efficacy of the Institute of Dermatology's Antioxidant Moisturizing Serum in Mild to Moderate Seborrheic Dermatitis
This 4-week split-face test will see if an antioxidant moisturizing serum helps reduce symptoms of mild to moderate facial seborrheic dermatitis in adults.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 13 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Institute of Dermatology, Thailand Government |
| Drugs / interventions | immunotherapy |
| Locations | 1 site (Ratchathewi, Bangkok) |
| Trial ID | NCT07433907 on ClinicalTrials.gov |
What this trial studies
This is a 4-week split-face randomized controlled comparison in which 13 adults with mild to moderate facial seborrheic dermatitis will apply the antioxidant serum to one side of the face and a control product to the other side. Clinical SEDASI scoring, standardized photographs, quality-of-life and satisfaction questionnaires, and bioengineering measures of skin barrier function and hydration will be collected at baseline and after 4 weeks. Bioengineering instruments and photography will be performed in climate-controlled facilities after subjects acclimatize for at least 30 minutes. Participants must stop topical anti-inflammatory treatments and antioxidant cosmetics at least two weeks before baseline and will be screened for exclusion criteria such as HIV, autoimmune disease, other skin disorders, or recent systemic immunotherapy.
Who should consider this trial
Good fit: Adults (≥18 years) with mild to moderate seborrheic dermatitis on the face who have not used topical anti-inflammatory treatments or antioxidant cosmetics for at least two weeks are ideal candidates.
Not a fit: Patients with severe disease, known immunosuppression (for example HIV), other autoimmune or skin diseases, or recent/ongoing systemic or regular topical anti-inflammatory therapy are unlikely to benefit from this small pilot.
Why it matters
Potential benefit: If successful, the serum could provide a gentle, non-steroidal option to improve symptoms and skin hydration for people with mild to moderate facial seborrheic dermatitis.
How similar studies have performed: Topical antioxidant approaches for seborrheic dermatitis are relatively novel and published evidence of success is limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria * Age: ≥ 18 years old * Gender: Male and Female * Patient who never uses or has stopped using topical corticosteroids/calcineurin inhibitor or other topical treatments exerting anti-inflammatory action (on the face) more than 2 weeks before entering this clinical trials. * Patient who does not use cosmetic containing any oxidants or others that exert anti-oxidant effect(s). If there is any, one must refrain from using them more than 2 weeks before entering this clinical trials. Exclusion Criteria * Patients with known cases of underlying HIV/AIDS, neurological condition e.g., Parkinson's disease. * Patient associated with any autoimmune diseases and other skin diseases * Patient takes any forms of oral immunotherapy more than 2 months up to the first day of clinical trials. * Patients continuously use of topical corticosteroids or other anti-inflammatory medicines on regular basis up to the first day of clinical trial. * Patient who refuses to stop using cosmetic(s) containing anti-oxidants or those exert anti-oxidant effect(s). * Patient who is allergic to the test product or one of its ingredients. * Pregnancy or nursing woman
Where this trial is running
Ratchathewi, Bangkok
- Institute of dermatology — Ratchathewi, Bangkok, Thailand (Recruiting)
Study contacts
- Principal investigator: Veng Ang Lok, Medical Doctor — Rangsit University
- Study coordinator: Veng Ang Lok, Medical Doctor
- Email: lokvengang@gmail.com
- Phone: +66839392488, +85598988089
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.