Anterior versus posterior white line advancement for correcting drooping upper eyelids (ptosis)
Official title: Comparative Study of the Efficacy of Anterior Versus Posterior White Line Advancement Technique in the Correction of Primary Aponeurotic Ptosis
Run by Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz · NCT07003308 · Data updated 2026-11-12
This study tests whether anterior or posterior white line advancement surgery better lifts and shapes upper eyelids in adults with primary aponeurotic ptosis.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 54 (estimated) |
| Sponsor | Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz Academic / other |
| Locations | 1 site (Móstoles, Madrid) |
| Status | Recruiting |
| Started | June 1, 2025 |
| Main results expected | December 30, 2026 |
| Study ends | January 30, 2027 |
| Registry record updated | October 7, 2025 |
| Trial ID | NCT07003308 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults over 18 with primary aponeurotic upper eyelid ptosis, levator function ≥12 mm, no prior ptosis surgery, and able to provide informed consent are ideal candidates.
✕Probably not a fit
People with non-aponeurotic ptosis, poor levator function, prior recurrent ptosis surgery, or other medical issues that preclude participation are unlikely to benefit from the results.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective, randomized 1:1 trial comparing two surgical approaches—anterior white line advancement through a skin crease incision and posterior white line advancement via a conjunctival incision—for primary aponeurotic upper eyelid ptosis. Participants receive one of the two procedures and are followed at 7 days, 2 months, and 6 months with objective eyelid position (MRD1), contour, and symmetry measurements, as well as vision and tear-film testing. Eyelid contour will be quantified using ImageJ with Bézier curve fitting and masked reviewers will provide subjective contour ratings, while patient-reported outcomes use the FACE-Q Aesthetics questionnaire. The primary outcome is change in MRD1 at 6 months, with secondary endpoints including contour, symmetry, patient satisfaction, and complication rates.
Why it matters
Potential benefit: If successful, the study could identify which technique gives better eyelid height, contour, and patient satisfaction with fewer complications, helping surgeons choose the optimal approach.
How similar studies have gone: Similar white line advancement techniques have reported good results in nonrandomized series, but randomized head-to-head comparisons are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age over 18 years. * Diagnosis of primary aponeurotic upper eyelid ptosis. * Levator muscle function of 12 mm or greater. * Provision of written informed consent after receiving adequate information about the study. Exclusion Criteria: * Diagnosis of non-aponeurotic eyelid ptosis. * Poor levator muscle function. * History of recurrent eyelid ptosis or previous eyelid ptosis surgery. * Medical or surgical history that, in the investigator's judgment, may interfere with participation. * Individuals with childbearing potential who are not using highly effective contraception methods. * Refusal to participate in the study or to sign the informed consent form.
Where it's running
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Rey Juan Carlos Hospital
Móstoles, Madrid, Spain Recruiting
Study contacts
- Principal investigator: Viviana Patricia Lezcano Carduz, MD — Rey Juan Carlos Hospital
- Study coordinator: Viviana Patricia Lezcano Carduz, MD
- Email: viviana.lezcano@quironsalud.es
- Phone: +34 914816225
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.