Anterior chamber deflation to help reattach Descemet's membrane after cataract surgery
Official title: Effect of Anterior Chamber Deflation Before Reduction of a Detached Descemet's Membrane
Run by Minia University · NCT07364708 · Data updated 2026-11-12
This trial tries two techniques—direct intracameral air injection versus anterior chamber deflation followed by air injection—to reattach Descemet's membrane in people aged 50–70 who develop this detachment within the first week after cataract surgery.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 50 Years and up |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | Minia University Academic / other |
| Locations | 1 site (Minya, None Selected) |
| Status | Recruiting |
| Started | July 20, 2025 |
| Main results expected | January 2026 |
| Study ends | February 2026 |
| Registry record updated | January 23, 2026 |
| Trial ID | NCT07364708 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 50–70 years old with a Descemet's membrane detachment diagnosed within the first postoperative week after cataract surgery, involving at least one-third of the membrane and without active infection, severe inflammation, or pre-existing glaucoma.
✕Probably not a fit
Patients with very small detachments (less than one-third of the membrane), active postoperative infection or severe inflammation, pre-existing glaucoma, or those presenting later than one week are unlikely to benefit from the interventions tested.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Participants diagnosed with Descemet's membrane detachment within one week of cataract surgery are assigned to one of two interventional groups: Group A receives direct intracameral air injection and Group B undergoes anterior chamber deflation followed by intracameral air injection. The trial compares the two techniques for reattachment success and short-term corneal outcomes. Primary outcomes likely include anatomic reattachment rate and corneal clarity, with follow-up visits to document visual recovery and complications. The procedures are performed at a single center under the oversight of Minia University clinical teams.
Why it matters
Potential benefit: If successful, the approach could produce faster and more reliable reattachment of Descemet's membrane, clearer corneas, and fewer repeat procedures.
How similar studies have gone: Intracameral air injection (descemetopexy) is an established technique for reattaching Descemet's membrane, while routine anterior chamber deflation before air injection has been reported less extensively and remains comparatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with post cataract surgery DM detachment diagnosed within 1st week postoperatively. * Patient age ranges from 50 to 70 years old. Exclusion Criteria: * Less than one third of Descemet's Membrane is included. * Post-operative infection or severe inflammation. * Patient with pre-existing glaucoma.
Where it's running
-
Khalafallah
Minya, None Selected, Egypt Recruiting
Study contacts
- Study coordinator: Ahmed Maher Khalafallah
- Email: drahmedmaher1988@gmail.com
- Phone: +201119094426
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.