Anterior chamber deflation to help reattach Descemet's membrane after cataract surgery

Effect of Anterior Chamber Deflation Before Reduction of a Detached Descemet's Membrane

This trial tries two techniques—direct intracameral air injection versus anterior chamber deflation followed by air injection—to reattach Descemet's membrane in people aged 50–70 who develop this detachment within the first week after cataract surgery.

Quick facts

• Phase: Not applicable
• Study type: Interventional
• Enrollment: 50 (estimated)
• Ages: 50 Years and up
• Sex: All
• Sponsor: Minia University (Academic / other)
• Locations: 1 site (Minya, None Selected)
• Trial ID: NCT07364708 on ClinicalTrials.gov

What this trial studies

Participants diagnosed with Descemet's membrane detachment within one week of cataract surgery are assigned to one of two interventional groups: Group A receives direct intracameral air injection and Group B undergoes anterior chamber deflation followed by intracameral air injection. The trial compares the two techniques for reattachment success and short-term corneal outcomes. Primary outcomes likely include anatomic reattachment rate and corneal clarity, with follow-up visits to document visual recovery and complications. The procedures are performed at a single center under the oversight of Minia University clinical teams.

Who should consider this trial

Good fit: Adults 50–70 years old with a Descemet's membrane detachment diagnosed within the first postoperative week after cataract surgery, involving at least one-third of the membrane and without active infection, severe inflammation, or pre-existing glaucoma.

Not a fit: Patients with very small detachments (less than one-third of the membrane), active postoperative infection or severe inflammation, pre-existing glaucoma, or those presenting later than one week are unlikely to benefit from the interventions tested.

Why it matters

Potential benefit: If successful, the approach could produce faster and more reliable reattachment of Descemet's membrane, clearer corneas, and fewer repeat procedures.

How similar studies have performed: Intracameral air injection (descemetopexy) is an established technique for reattaching Descemet's membrane, while routine anterior chamber deflation before air injection has been reported less extensively and remains comparatively novel.

Eligibility criteria

Inclusion Criteria:

* Patients with post cataract surgery DM detachment diagnosed within 1st week postoperatively.
* Patient age ranges from 50 to 70 years old.

Exclusion Criteria:

* Less than one third of Descemet's Membrane is included.
* Post-operative infection or severe inflammation.
* Patient with pre-existing glaucoma.

Where this trial is running

Minya, None Selected

• Khalafallah — Minya, None Selected, Egypt (Recruiting)

Study contacts

• Study coordinator: Ahmed Maher Khalafallah

Conditions Descemet's Membrane Disorder