Antecolic versus Retrocolic Gastrojejunostomy after a Whipple (pancreaticoduodenectomy)
Antecolic Versus Retrocolic Gastrojejunostomy Following Pancreaticoduodenectomy: a Prospective Randomised Study
This trial tests whether routing the stomach-to-small-intestine connection in front of (antecolic) or behind (retrocolic) the colon changes the chance of delayed gastric emptying in adults having a Whipple operation for pancreatic cancer.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 76 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | University of Thessaly Academic / other |
| Locations | 1 site (Larissa) |
| Trial ID | NCT06914349 on ClinicalTrials.gov |
What this trial studies
This is a randomized trial at the University Hospital of Larissa comparing two ways to reconstruct the gastrointestinal tract after pylorus-preserving pancreaticoduodenectomy: antecolic versus retrocolic gastrojejunostomy. Adult patients undergoing elective Whipple surgery are randomized to one of the two reconstruction routes and followed for the occurrence of delayed gastric emptying (DGE). The study excludes patients under 18 or over 75 years and those who do not consent or are enrolled in conflicting trials. The primary comparison is the rate of DGE between the two groups, and outcomes are analyzed to see if one method leads to fewer postoperative gastric emptying problems.
Who should consider this trial
Good fit: Adults (age 18–75) scheduled for elective pylorus-preserving pancreaticoduodenectomy who can give informed consent and are not enrolled in conflicting studies are the intended participants.
Not a fit: Patients under 18 or over 75, those having non-pylorus-preserving or emergency pancreatic surgery, or those with contraindications to either reconstruction are unlikely to benefit from joining this trial.
Why it matters
Potential benefit: If one route causes less delayed gastric emptying, patients could have faster recovery, shorter hospital stays, and fewer feeding complications after surgery.
How similar studies have performed: Previous surgical series and some randomized reports have hinted that antecolic reconstruction may lower DGE rates, but results have been inconsistent and not definitively conclusive.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age over 18 years old * Elective pancreaticoduodenectomy * Signed consent form Exclusion Criteria: * Age under 18 years old * Patients who are participants in other trials that may affect the results of this study * Patients who do not consent to participate in the study
Where this trial is running
Larissa
- University of Thessaly — Larissa, Greece (Recruiting)
Study contacts
- Study coordinator: Chrysoula C Kolla
- Email: christinakolla@yahoo.gr
- Phone: +306983075706
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.