Antecolic versus Retrocolic Gastrojejunostomy after a Whipple (pancreaticoduodenectomy)
Official title: Antecolic Versus Retrocolic Gastrojejunostomy Following Pancreaticoduodenectomy: a Prospective Randomised Study
Run by University of Thessaly · NCT06914349 · Data updated 2026-11-12
This trial tests whether routing the stomach-to-small-intestine connection in front of (antecolic) or behind (retrocolic) the colon changes the chance of delayed gastric emptying in adults having a Whipple operation for pancreatic cancer.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 80 Years |
| Sex | All |
| Enrollment | 76 (estimated) |
| Sponsor | University of Thessaly Academic / other |
| Locations | 1 site (Larissa) |
| Status | Recruiting |
| Started | March 30, 2025 |
| Main results expected | March 31, 2028 |
| Study ends | March 31, 2029 |
| Registry record updated | June 6, 2025 |
| Trial ID | NCT06914349 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (age 18–75) scheduled for elective pylorus-preserving pancreaticoduodenectomy who can give informed consent and are not enrolled in conflicting studies are the intended participants.
✕Probably not a fit
Patients under 18 or over 75, those having non-pylorus-preserving or emergency pancreatic surgery, or those with contraindications to either reconstruction are unlikely to benefit from joining this trial.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a randomized trial at the University Hospital of Larissa comparing two ways to reconstruct the gastrointestinal tract after pylorus-preserving pancreaticoduodenectomy: antecolic versus retrocolic gastrojejunostomy. Adult patients undergoing elective Whipple surgery are randomized to one of the two reconstruction routes and followed for the occurrence of delayed gastric emptying (DGE). The study excludes patients under 18 or over 75 years and those who do not consent or are enrolled in conflicting trials. The primary comparison is the rate of DGE between the two groups, and outcomes are analyzed to see if one method leads to fewer postoperative gastric emptying problems.
Why it matters
Potential benefit: If one route causes less delayed gastric emptying, patients could have faster recovery, shorter hospital stays, and fewer feeding complications after surgery.
How similar studies have gone: Previous surgical series and some randomized reports have hinted that antecolic reconstruction may lower DGE rates, but results have been inconsistent and not definitively conclusive.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age over 18 years old * Elective pancreaticoduodenectomy * Signed consent form Exclusion Criteria: * Age under 18 years old * Patients who are participants in other trials that may affect the results of this study * Patients who do not consent to participate in the study
Where it's running
-
University of Thessaly
Larissa, Greece Recruiting
Study contacts
- Study coordinator: Chrysoula C Kolla
- Email: christinakolla@yahoo.gr
- Phone: +306983075706
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.