Anesthesia type effects on oxidative stress during VATS
Total Intravenous Anesthesia (TIVA), Combined Intravenous-Volatile Anesthesia (CIVA), and Balanced Anesthesia (BAL) on Perioperative Oxidative Stress in Video-Assisted Thoracoscopic Surgery (VATS)
This test compares three anesthesia methods—total intravenous (TIVA), combined intravenous-volatile (CIVA), and balanced anesthesia—to see if they change oxidative stress in adults having VATS with one-lung ventilation.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Ataturk University Academic / other |
| Locations | 1 site (Erzurum) |
| Trial ID | NCT07271472 on ClinicalTrials.gov |
What this trial studies
Adults undergoing elective video-assisted thoracoscopic surgery who require one-lung ventilation for over 60 minutes will be assigned to receive TIVA, CIVA, or balanced anesthesia. Perioperative blood samples will measure oxidative stress markers including malondialdehyde (MDA), total oxidant status (TOS), total antioxidant status (TAS), and superoxide dismutase (SOD). Vital signs and arterial blood gas values will be recorded at specific surgical stages and postoperative nausea and vomiting will be tracked. The trial is single-center at Ataturk University and enrolls ASA I–II patients aged 18–65.
Who should consider this trial
Good fit: Adults aged 18–65 with ASA I–II scheduled for elective VATS requiring one-lung ventilation for more than 60 minutes are ideal candidates.
Not a fit: Patients outside that age range, with ASA III–IV or severe cardiac, renal, or hepatic disease, allergies to the study drugs, or recent vitamin supplementation are unlikely to benefit or be eligible.
Why it matters
Potential benefit: If successful, the results could identify an anesthesia approach that reduces perioperative oxidative lung injury and improves oxygenation and recovery after VATS.
How similar studies have performed: Animal studies indicate volatile anesthetics can alter hypoxic pulmonary vasoconstriction, but human results are inconsistent and direct comparisons of oxidative stress across these anesthesia approaches in VATS are relatively limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged between 18 and 65 years, * American Society of Anesthesiologists (ASA) Physical Status Class I-II, * Scheduled for elective Video-Assisted Thoracoscopic Surgery (VATS) * Requiring one-lung ventilation for more than 60 minutes Exclusion Criteria: * Refusal to participate in the study * History of allergy to the drugs to be used * Recent history of vitamin supplementation * History of severe cardiac, renal, or hepatic disease * ASA III-IV
Where this trial is running
Erzurum
- Ataturk University — Erzurum, Turkey (Türkiye) (Recruiting)
Study contacts
- Principal investigator: Elif Oral Ahiskalioglu, Professor — Ataturk University
- Study coordinator: Elif Oral Ahiskalioglu, Professor
- Email: drelforl@hotmail.com
- Phone: +90-505-925-96-32
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.