Analyzing vitreous fluid to identify biomarkers in retinal diseases
Official title: Nuclear Magnetic Resonance (NMR)-Based Metabolomic Characterisation of Vitreoretinal Diseases Using Vitreous Fluid
Run by Renmin Hospital of Wuhan University · NCT06429969 · Data updated 2026-11-12
This study is trying to find specific markers in the eye fluid of people with different retinal diseases to help understand these conditions better.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 40 Years to 90 Years |
| Sex | All |
| Enrollment | 450 (estimated) |
| Sponsor | Renmin Hospital of Wuhan University Academic / other |
| Locations | 1 site (Wuhan, Hubei) |
| Status | Recruiting |
| Started | January 17, 2024 |
| Main results expected | April 17, 2027 |
| Study ends | December 31, 2027 |
| Registry record updated | May 28, 2024 |
| Trial ID | NCT06429969 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are patients diagnosed with vitreoretinal diseases who require pars plana vitrectomy.
✕Probably not a fit
Patients with vitreoretinal diseases that do not require surgery or those with a history of previous vitrectomy may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to investigate the metabolomic profiles of various vitreoretinal diseases using nuclear magnetic resonance (NMR) analysis of vitreous fluid. Participants diagnosed with conditions such as idiopathic macular hole, diabetic retinopathy, retinal detachment, idiopathic macular epiretinal membrane, and retinal vein occlusion, who require pars plana vitrectomy, will have their vitreous samples collected for analysis. The study will categorize participants into groups based on their specific diagnoses and compare metabolomic differences to identify potential biomarkers for these diseases. No interventions will be performed, as the study focuses solely on preoperative data collection and analysis of leftover vitreous fluid.
Why it matters
Potential benefit: If successful, this study could lead to the identification of biomarkers that improve the prevention, early diagnosis, and treatment of vitreoretinal diseases.
How similar studies have gone: While the approach of using metabolomics in vitreous fluid analysis is relatively novel, similar studies in other areas have shown promise in identifying biomarkers for various diseases.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Confirmation of IMH diagnosis with concomitant need for PPV surgery; 2. Confirmation of DR diagnosis with concomitant need for PPV surgery; 3. Confirmation of RD diagnosis with concomitant need for PPV surgery; 4. Confirmation of IMM diagnosis with concomitant need for PPV surgery; 5. Confirmation of RVO diagnosis with concomitant need for PPV surgery. Exclusion Criteria: 1. Diagnosed vitreoretinal disease with no need for PPV surgery; 2. Previous history of PPV surgery; 3. Combination of other active ophthalmic diseases, such as acute conjunctivitis and uveitis; 4. Combination of serious systemic diseases such as hypertension and diabetes mellitus.
Where it's running
-
Eye, Center, Renmin Hospital of Wuhan University
Wuhan, Hubei, China Recruiting
Study contacts
- Principal investigator: Lei Du — Renmin Hospital of Wuhan University
- Study coordinator: Liwei Cheng
- Email: wdrmiit@163.com
- Phone: 027-88041911
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.