Analyzing Urolithin Levels After Eating Pecans
Postprandial Urolithin Response to a Pecan-Enriched Meal
NA · University of Georgia · NCT06140602
This study is testing how eating pecans affects the levels of certain compounds in the blood of healthy young adults to see if it can help track pecan consumption in diets.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 18 Years to 30 Years |
| Sex | All |
| Sponsor | University of Georgia (other) |
| Locations | 1 site (Athens, Georgia) |
| Trial ID | NCT06140602 on ClinicalTrials.gov |
What this trial studies
This study investigates how consuming pecans affects the levels of urolithins, metabolites derived from ellagic acid, in human plasma. It employs a double-blinded, randomized crossover design with 30 healthy participants aged 18-30, who will consume two different breakfast shakes on separate occasions. Blood samples will be taken after each meal to measure the postprandial response of urolithins and compare it to traditional plasma tocopherol levels. The goal is to establish a reliable biomarker for pecan consumption that can be used in dietary assessments.
Who should consider this trial
Good fit: Ideal candidates are healthy individuals aged 18-30 with a BMI between 18.5 and 29.9 who do not take certain medications or have gastrointestinal diseases.
Not a fit: Patients with a BMI outside the specified range or those with chronic gastrointestinal diseases will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a new dietary biomarker for pecan consumption, enhancing nutritional assessments and dietary recommendations.
How similar studies have performed: While studies have explored the effects of pecans on health, this specific approach to measuring urolithins post-consumption is novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Healthy individuals with BMI between 18.5 - 29.9 kg/m2 * Does not make use of medication (Birth control, and antidepressants SSRIs accepted) * Does not make use of any nicotine products * Has not been diagnosed with any diseases that can impair swallowing, digestion or lipid metabolism Exclusion Criteria: * Individuals with BMI \< 18.5 or BMI \> 29.9 kg/m2 * Individuals with chronic diseases of the gastrointestinal system * Individuals currently taking antibiotics or any other medications not included on the inclusion criteria * Individuals that have a current fever, or have any infection * Individuals can not be taking prebiotics/probiotics supplementation, as well as multivitamin.
Where this trial is running
Athens, Georgia
- Human Nutrition Lab — Athens, Georgia, United States (RECRUITING)
Study contacts
- Principal investigator: Chad M Paton, PhD — University of Georgia
- Study coordinator: Chad M Paton, PhD
- Email: Cpaton@uga.edu
- Phone: 7065423750
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Change in Plasma Urolithins and Vitamin E, Urolithins, Pecans, Dietary biomarker, Tocopherols