Analyzing tonsil tissue in children with sleep apnea
Single Cell Sequencing to Examine the Pathogenesis of Adenotonsillar Hypertrophy in Children With Obstructive Sleep Apnoea
This study is trying to understand the tonsil tissue in children aged 6-11 with sleep apnea to see how it differs from kids having their tonsils removed for other reasons.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 15 (estimated) |
| Ages | 6 Years to 11 Years |
| Sex | All |
| Sponsor | Chinese University of Hong Kong Academic / other |
| Locations | 1 site (Hong Kong) |
| Trial ID | NCT05115968 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on children aged 6-11 years with obstructive sleep apnea (OSA) and adenotonsillar hypertrophy. It aims to utilize single-cell sequencing to investigate the cellular composition and immune response in tonsillar tissue, which may help uncover the underlying mechanisms of adenotonsillar hypertrophy in these patients. By comparing samples from children with OSA to those undergoing tonsillectomy for other reasons, the study seeks to identify specific cell expression patterns associated with the condition. The findings could lead to a better understanding of OSA pathogenesis and inform future therapeutic strategies.
Who should consider this trial
Good fit: Ideal candidates include Chinese children aged 6-11 years with habitual snoring and polysomnography-confirmed OSA who require adenotonsillectomy.
Not a fit: Patients with previous upper airway surgery, genetic syndromes, or other specified health conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to novel therapies for children suffering from obstructive sleep apnea.
How similar studies have performed: While similar studies have explored cellular mechanisms in sleep apnea, this specific approach using single-cell sequencing in pediatric patients is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Case: Chinese children aged 6-11 years old with habitual snoring (≥3 nights per week) and polysomnography (PSG) confirmed OSA (obstructive apnoea hypopnoea index (OAHI) of ≥1/hour), with adenotonsillar hypertrophy and clinical indications for adenotonsillectomy will be recruited as cases. Control: Non-OSA subjects (with PSG OAHI \<1/hour) who undergo adenotonsillectomy for other reasons such as recurrent tonsillitis. Exclusion Criteria: Previous upper airway surgery, genetic or syndromal disease, congenital or acquired neuromuscular disease, congenital or acquired immunodeficiency, known metabolic syndrome, craniofacial abnormalities.
Where this trial is running
Hong Kong
- Prince of Wales Hospital — Hong Kong, Hong Kong (Recruiting)
Study contacts
- Principal investigator: Kate C Chan, MBChB — Chinese University of Hong Kong
- Study coordinator: Kate C Chan, MBChB
- Email: katechan@cuhk.edu.hk
- Phone: 35052840
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.