Analyzing the role of the sympathetic nervous system in spontaneous coronary artery dissection
Role of the Neurovascular System in Spontaneous Coronary Artery Dissection (SCAD)
NA · Mayo Clinic · NCT05699200
This study is testing how the sympathetic nervous system affects heart health in people who have had spontaneous coronary artery dissection compared to similar individuals without the condition.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 50 (estimated) |
| Ages | 18 Years and up |
| Sex | Female |
| Sponsor | Mayo Clinic (other) |
| Locations | 1 site (Rochester, Minnesota) |
| Trial ID | NCT05699200 on ClinicalTrials.gov |
What this trial studies
This research compares the sympathetic nervous system function and arterial health between participants with a history of spontaneous coronary artery dissection (SCAD) and age- and sex-matched controls. The study employs various interventions, including arterial tonometry, echocardiograms, carotid ultrasounds, elastography, and ankle-brachial index measurements to assess differences in cardiovascular health. By understanding these differences, the study aims to shed light on the underlying mechanisms of SCAD.
Who should consider this trial
Good fit: Ideal candidates include individuals with a confirmed history of spontaneous coronary artery dissection and healthy participants without any cardiac disease history.
Not a fit: Patients who are pregnant, have unstable cardiac conditions, or are currently on anticoagulation or dual antiplatelet therapy may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of spontaneous coronary artery dissection, potentially enhancing patient outcomes.
How similar studies have performed: While this study explores a specific aspect of SCAD, similar studies have shown promise in understanding cardiovascular conditions, indicating potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * For SCAD patients: history of SCAD as confirmed by coronary angiography or cardiac computed tomography angiography * For controls: no cardiac disease history Exclusion Criteria: * Pregnancy * Known or suspected unstable cardiac condition within 4 weeks of the study * Active treatment with anticoagulation or dual antiplatelet therapy * Prisoner
Where this trial is running
Rochester, Minnesota
- Mayo Clinic Rochester — Rochester, Minnesota, United States (RECRUITING)
Study contacts
- Principal investigator: Marysia Tweet, MD, MS — Mayo Clinic
- Study coordinator: Pamela Engrav
- Email: Engrav.Pamela@mayo.edu
- Phone: 507-255-6938
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Spontaneous Coronary Artery Dissection, Healthy