Analyzing the role of the sympathetic nervous system in spontaneous coronary artery dissection

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This research compares the sympathetic nervous system function and arterial health between participants with a history of spontaneous coronary artery dissection (SCAD) and age- and sex-matched controls. The study employs various interventions, including arterial tonometry, echocardiograms, carotid ultrasounds, elastography, and ankle-brachial index measurements to assess differences in cardiovascular health. By understanding these differences, the study aims to shed light on the underlying mechanisms of SCAD.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* For SCAD patients: history of SCAD as confirmed by coronary angiography or cardiac computed tomography angiography
* For controls: no cardiac disease history

Exclusion Criteria:

* Pregnancy
* Known or suspected unstable cardiac condition within 4 weeks of the study
* Active treatment with anticoagulation or dual antiplatelet therapy
* Prisoner

Where it's running

• Mayo Clinic Rochester
  Rochester, Minnesota, United States Recruiting

Study contacts

• Principal investigator: Marysia Tweet, MD, MS — Mayo Clinic
• Study coordinator: Pamela Engrav
• Email: Engrav.Pamela@mayo.edu
• Phone: 507-255-6938

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Survey of physical activity and quality of life for people with fibromuscular dysplasia

  This national survey asks adults with fibromuscular dysplasia to see if activity restrictions affect their quality of life and emotional well-being.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT07529691

• Exercise responses in people with spontaneous coronary artery dissection or fibromuscular dysplasia

  This study will test whether short sessions of different aerobic and resistance exercise change breathing, heart and blood pressure responses and symptoms in people with SCAD or FMD.

  Recruiting Mayo Clinic · Jacksonville, Florida · NCT07526766

• Stress contrast echocardiography in adults with prior SCAD

  This project will use stress contrast echocardiography to see if small-vessel heart blood flow and blood-pressure responses during stress are different in adults who had spontaneous coronary artery dissection (SCAD) compared with healthy adults.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07178509

• Remote exercise program after spontaneous coronary artery dissection

  This study tests a remote exercise program to see if it’s doable for women recovering from SCAD events.

  Recruiting University of Leicester · Leicester, Leicestershire · NCT06955663

• Registry for Spontaneous Coronary Artery Dissection

  This study is setting up a large registry to collect information from women who have experienced spontaneous coronary artery dissection to better understand the condition and improve treatment options.

  Recruiting at 68 sites European Society of Cardiology · Buenos Aires and 72 other locations · NCT06601270

• Observational study on spontaneous coronary artery dissection

  This study is trying to learn more about spontaneous coronary artery dissection (SCAD) by following 3,000 patients over 10 years to better understand who it affects and how to treat it.

  Recruiting Cardiology Research UBC · Vancouver, British Columbia · NCT04906356

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.