Analyzing the relationship between gut bacteria and immune response in patients with a specific type of dermatomyositis and lung disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate how the microbial community in the body interacts with the immune system in patients who have anti-MDA5 antibody positive dermatomyositis and concurrent rapidly progressive interstitial lung disease. Researchers will collect bronchoalveolar lavage specimens from these patients to analyze the composition of their microecology and its potential impact on disease progression. The study focuses on understanding the connection between microbiome diversity and immune function in this specific patient population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients who meet the diagnostic criteria of dermatomyositis and anti-MDA 5 antibody positive.
* Anti-MDA5 antibody positive DM patients with RPILD meet the diagnostic criteria for RPILD.
* Must have undergone bronchoalveolar lavage.
* Age≥18 years old.
* Patients who signed informed consent forms

Exclusion Criteria:

* Patients who had other connective tissue diseases.
* Patients with ILD or RPILD caused by infection, tumors, drugs, biochemistry and other factors.
* Pregnant or lactating patients.
* The patient also participated in any other clinical trial.
* Disagreement for inclusion in this study

Where it's running

• Pla
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Study coordinator: Zhimei Duan, doctor
• Email: 549117002@qq.com
• Phone: 13716376758

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.