Analyzing the microenvironment of lung cancer and resistance to immunotherapy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to conduct a multiomics analysis, including genomics, proteomics, and single-cell RNA sequencing, of tumor tissue and blood from lung cancer patients. The goal is to analyze tumor heterogeneity and map the tumor microenvironment to explore mechanisms of sensitivity and resistance to anti-PD-1/PD-L1 antibodies. By characterizing the entire tumor ecosystem, the study seeks to identify predictive biomarkers for immunotherapy responses and understand the individualized nature of treatment outcomes in lung cancer patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Histopathology or hemology diagnostics of lung cancer
* Patients have never received any antineoplastic therapy

Exclusion Criteria:

* Within 5 years or at the same time, there are other active malignancies
* Currently participating in interventional clinical research treatment, or received other research drugs or used research devices within 4 weeks before the first administration
* Active autoimmune diseases requiring systemic treatment (such as the use of disease relieving drugs, glucocorticoids or immunosuppressants) occurred within 2 years before the first administration
* The study was receiving systemic glucocorticoid treatment (excluding local glucocorticoids by nasal spray, inhalation or other means) or any other form of immunosuppressive therapy within 7 days before the first administration; Note: It is allowed to use glucocorticoid with physiological dose (prednisone ≤ 10mg/day or equivalent)
* Known history of allogeneic organ transplantation and allogeneic hematopoietic stem cell transplantation

Where it's running

• The Fourth Affiliated Hospital of Zhejiang University
  Yiwu, Zhejiang, China Recruiting

Study contacts

• Principal investigator: Kai Wang, PhD — The Fourth Affiliated Hospital of Zhejiang University School of Medicine
• Study coordinator: Kai Wang, PhD
• Email: doctorhuxi@163.com
• Phone: 13957158572

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.