Analyzing the Function of a Neck Muscle in Cervical Dystonia
STOCI: Three-dimensional Analysis of Obliquus Capitis Inferior Muscle Function in the Rotatory Form of Cervical Dystonia by Means of the Cone Beam Mode CT Scanning :Prospective Cohort Study
This study looks at how a specific neck muscle works in people with cervical dystonia to see if it can help improve treatments like botulinum toxin injections.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 30 (estimated) |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Sponsor | Fondation Ophtalmologique Adolphe de Rothschild Research network |
| Locations | 1 site (Paris) |
| Trial ID | NCT05327985 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on understanding the function of the obliquus capitis inferior muscle in patients with cervical dystonia, a condition characterized by involuntary neck muscle contractions. The study aims to identify specific muscle involvement in patients receiving botulinum toxin injections for treatment. By utilizing advanced imaging techniques, the research seeks to provide insights that could enhance therapeutic interventions for this condition. The findings may help tailor treatment strategies based on individual muscle patterns.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 to 70 diagnosed with focal cervical dystonia exhibiting predominantly rotational symptoms.
Not a fit: Patients with mobile dystonia, severe neck pain, or other neurological conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more effective and personalized treatment options for patients with cervical dystonia.
How similar studies have performed: While similar studies have explored muscle function in dystonia, this specific analysis of the obliquus capitis inferior muscle is novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients between the ages of 18 and 70 * Presenting with a diagnosed focal CD with predominantly rotational by a neurologist specialized in abnormal movements * Receiving botulinum toxin injection at OIC level as part of his treatment * Express consent to participate in the study * Member of or beneficiary of a social security scheme Exclusion Criteria: * Mobile DC (scrapie and/or myoclonic) that cannot be controlled the recording time by the CBCT system * Having already benefited from an injection of BoNT as part of their DC in the last three months * Inability to sit still * Neurological condition other than DC (parkinsonian syndrome typical or atypical, others.) * Severe neck pain * Known or suspected trauma or pathology of the cervical spine, other than DC, having required treatment in the last 6 month * Same old surgery of the cervical spine * Patient benefiting from a legal protection measure * Pregnant or breastfeeding women (a urine pregnancy test will be carried out in women under 50)
Where this trial is running
Paris
- Hopital Fondation Adolphe de Rothschild — Paris, France (Recruiting)
Study contacts
- Principal investigator: Jean Pierre Bleton — Hopital Fondation Adolphe de Rothschild
- Study coordinator: Amelie YAVCHITZ, DR
- Email: ayavchitz@for.paris
- Phone: 01 48 03 64 54
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.