Analyzing Sympathetic Activity in Willis-Ekbom Disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the sympathetic nervous system activity in patients with Willis-Ekbom Disease (WED), also known as restless legs syndrome (RLS). It aims to understand the relationship between WED and cardiovascular risks by measuring sympathetic activity and its potential impact on sleep quality and overall health. Participants will include individuals diagnosed with idiopathic WED who meet specific inclusion criteria, and the study will utilize a case-control design to compare findings. The research seeks to clarify the pathophysiology of WED and its association with cardiovascular diseases.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Non-specific inclusion criteria (CASE + CONTROL)

  * 18 years-old or more, and less than 75 years-old
  * French-speaking
  * able to understand the study
  * signed written informed consent
  * affiliated to social security
* CASE-specific inclusion criteria

  * 5 " International RLS Study Group (IRLSSG) 2012 " positive criteria
  * RLS severity scale (IRLS) score ≥ 15
  * ferritin \> 50 ng/ml
  * periodic limb movements index \> 10/hour
  * idiopathic (or primary) Willis-Ekbom disease not treated with dopaminergic agonists or pregabalin or gabapentin in the last 8 days, at least 3 years of disease duration with symptoms recurring at least 3 times a week

Exclusion Criteria:

* Non-specific exclusion criteria (CASE + CONTROL)

  * vulnerable subject : subject deprived of liberty or protected by law (trusteeship, legal guardianship), pregnant or breastfeeding woman
  * exclusion period after other research protocol
  * malignant neoplastic disease treated in the last 12 months
  * medical history of cardiovascular disease (ischemic heart disease, heart failure, stroke, hypertension, sleep apnea syndrome)
  * antidepressant, neuroleptic, sympathomimetic, sympatholytic, vasculotropic, dopamine agonists, opiate treatments
* CASE-specific exclusion criteria

  \- restless legs syndrome secondary to renal failure, hemochromatosis, neurologic disorders, iatrogenesis
* CONTROL-specific exclusion criteria - Willis-Ekbom Disease

Where it's running

• University Hospital of Montpellier
  Montpellier, France Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Interoceptive network connectivity in restless legs syndrome

  This project will test whether insular brain connectivity and people's ability to sense their internal body signals differ across the day in adults with restless legs syndrome compared with healthy adults.

  Recruiting University Hospital, Bordeaux · Bordeaux · NCT07001891

• Buddhist walking meditation for restless leg syndrome in hemodialysis patients

  This study is testing if Buddhist walking meditation can help people with restless leg syndrome who are on hemodialysis feel better.

  Recruiting Cairo University · Dokki, Giza Governorate · NCT06806891

• Understanding Restless Leg Syndrome in Thai Patients with Parkinson's Disease

  This study looks at how common Restless Legs Syndrome is in Thai people with Parkinson's Disease to better understand and manage this condition.

  Recruiting at 2 sites Siriraj Hospital · Bangkok, Bangkok and 1 other locations · NCT06684782

• Understanding blood changes after exercise in people with restless legs syndrome

  This study tests how regular exercise affects blood proteins in people with restless legs syndrome compared to those who don’t exercise.

  Recruiting Stanford University · Stanford, California · NCT06481176

• Using electrical stimulation to improve muscle function in stroke patients

  This study is testing if a special type of electrical stimulation can help stroke patients improve their muscle control and mobility.

  Recruiting University of Lausanne · Lausanne · NCT05908214

• Using mobile technology to assess symptoms in patients with Restless Legs Syndrome

  This study is testing if using a mobile app can help people with Restless Legs Syndrome track their symptoms and see how daily habits like exercise and sleep affect their condition.

  Recruiting University Hospital, Bordeaux · Bordeaux · NCT05695963

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.