Analyzing pain levels after different root canal irrigation methods

Incidence of Postoperative Pain After Activation of Irrigant With Apical Negative Pressure and Ultrasonics in Mandibular Molar Teeth With Irreversible Pulpitis: A Randomized Controlled Trial

Not applicable Interventional Cleveland Dental Institute · NCT06528574

This study is testing if a new way to clean teeth during root canal treatment can help reduce pain for patients compared to traditional methods.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment84 (estimated)
Ages18 Years to 50 Years
SexAll
SponsorCleveland Dental Institute Academic / other
Locations1 site (Cleveland, Ohio)
Trial IDNCT06528574 on ClinicalTrials.gov

What this trial studies

This study investigates postoperative pain levels in patients undergoing root canal therapy using various irrigation techniques, including the new Dent's iVac irrigation protocol. It compares the effectiveness of this new method against traditional, ultrasonic, and negative pressure irrigation techniques. Pain will be measured using a standardized numerical rating scale at multiple time intervals following the procedure. The goal is to determine if the new irrigation approach can significantly reduce pain after treatment.

Who should consider this trial

Good fit: Ideal candidates are males and females aged 20-50 with symptomatic acute pulpitis in mandibular mature first molars.

Not a fit: Patients with pulp necrosis, apical periodontitis, periodontal disease, or other significant dental issues may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved pain management strategies for patients undergoing root canal therapy.

How similar studies have performed: While there is ongoing research in pain management techniques for root canal therapy, the specific approach of the Dent's iVac irrigation protocol is novel and has not been extensively tested.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

Males and females Age :20-50 Mandibular mature first molars with symptomatic acute pulpitis Medically free patients

Exclusion Criteria:

Pulp necrosis or apical periodontitis Periodontal disease Vertical root fracture Radiographic apical radiolucency

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Where this trial is running

Cleveland, Ohio

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Pain
Last reviewed 2026-06-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.