Analyzing ocular surface biomarkers for cataract surgery
Metabo-lipidomic Analysis of the Ocular Surface and Aqueous Humor for the Search of Predictive Biomarkers of Ocular Surface Disease After Cataract Surgery: a Prospective Cohort Study
This study is testing if certain eye surface markers can help predict the risk of problems after cataract surgery to improve recovery and quality of life for patients.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 100 (estimated) |
| Ages | 50 Years and up |
| Sex | All |
| Sponsor | University Hospital, Tours Academic / other |
| Locations | 1 site (Tours) |
| Trial ID | NCT05802550 on ClinicalTrials.gov |
What this trial studies
This study investigates the ocular surface of patients undergoing cataract surgery to identify biomarkers that may predict the risk of postoperative ocular surface disease. By utilizing conjunctival impression cytology and collecting aqueous humor, researchers aim to develop a better understanding of how these factors influence visual recovery and quality of life after surgery. The goal is to personalize perioperative care based on the identified biomarkers, potentially improving outcomes for patients. This approach combines advanced metabolomic techniques with clinical assessments to enhance patient care.
Who should consider this trial
Good fit: Ideal candidates for this study are patients aged 50 and older with cortico-nuclear and/or subcapsular age-related cataracts.
Not a fit: Patients with a history of recent ocular surgery, other types of cataracts, or conditions affecting the ocular surface may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved personalized care for cataract surgery patients, reducing the risk of postoperative ocular surface disease.
How similar studies have performed: While the specific approach of this study may be novel, similar studies have shown promise in identifying ocular surface biomarkers in other contexts.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion criteria: * Patient with cortico-nuclear and/or subcapsular cataract * Age \> or = 50 years * Patient affiliated to a social security system * Patient agreeing to participate in the study who provided his/her free and informed written consent Exclusion criteria: * History of ocular surgery or trauma (≤ 3 months) * Other types of cataract excepted age-related or diabetic cataract * Any eye drops or treatments that may interfere with the ocular surface * Lens wearer * Any general pathology with a known impact on the ocular surface (auto-immune disease, allergy) * Proven allergy to povidone-iodine or to a component of the postoperative treatment * Patient under legal protection (safeguard of justice, curatorship and guardianship), or in a situation of deprivation of freedom * Patient unable to understand the nature and objectives of the study
Where this trial is running
Tours
- Khanna — Tours, France (Recruiting)
Study contacts
- Study coordinator: Raoul Kanav Khanna
- Email: raoul.khanna@univ-tours.fr
- Phone: 02 47 47 27 67
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.