Analyzing nasal mucus proteins in allergic rhinitis and immunotherapy
Seasonal Differences in Nasal Mucus Proteome and Impact of Immunotherapy
This study is trying to see how the proteins in nasal mucus change in people with allergic rhinitis during different seasons and after they receive immunotherapy.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 88 (estimated) |
| Ages | 18 Years to 100 Years |
| Sex | All |
| Sponsor | Medical University of Graz Academic / other |
| Drugs / interventions | immunotherapy |
| Locations | 1 site (Graz, Styria) |
| Trial ID | NCT02159404 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the changes in the nasal mucus proteome of patients with allergic rhinitis compared to healthy controls during both pollen and non-pollen seasons. By collecting nasal mucus using a specialized suction device, researchers will perform proteomic analysis to identify distinct proteins and assess how these proteins change in response to immunotherapy. The study seeks to provide insights into potential biomarkers for diagnostics and therapy, enhancing our understanding of the immune response in allergic rhinitis.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals with verified pollen allergies who are eligible for immunotherapy.
Not a fit: Patients with chronic infectious diseases, poor overall health, or those on long-term medications that affect nasal function may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic and therapeutic strategies for patients with allergic rhinitis.
How similar studies have performed: While this approach is innovative, similar studies have shown promise in understanding the proteomic changes associated with allergic conditions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * pollen allergy verified by skin-prick test, blood tests for specific IgE (RAST) and allergic rhinitis symptoms, eligible for immunotherapy Exclusion Criteria: * chronic infectious diseases, bad overall health condition, pregnancy, long-term intake of nasal and/or systemic steroids or antihistamines, acute and/or chronic rhinosinusitis and parallel participation in other studies
Where this trial is running
Graz, Styria
- ENT University Hospital Graz — Graz, Styria, Austria (Recruiting)
Study contacts
- Study coordinator: Peter V Tomazic, M.D.
- Email: peter.tomazic@medunigraz.at
- Phone: +4331638581347
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.