Analyzing muscle contractions to detect tremors in Parkinson's disease
Detecting the Rest Tremor Associated With Parkinson's Disease Using Analysis of the Muscle Contractions Rhythmicity
This study is testing a way to measure and understand the muscle movements of people with Parkinson's disease to see how their resting tremors differ from other types of tremors.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 80 (estimated) |
| Ages | 18 Years to 100 Years |
| Sex | All |
| Sponsor | Henri Mondor University Hospital Academic / other |
| Locations | 1 site (Créteil) |
| Trial ID | NCT05998486 on ClinicalTrials.gov |
What this trial studies
This observational study aims to quantify and track resting tremors associated with Parkinson's disease by analyzing the rhythmicity of muscle contractions in the upper limb. It utilizes surface EMG recordings from wrist flexor-pronators and extensor-supinators under various conditions to differentiate between resting tremors and cerebellar tremors. The rhythmicity index (RI) is calculated to assess the frequency spectrum of the EMG signals, providing insights into the nature of the tremors. The study focuses on patients diagnosed with Parkinson's disease or cerebellar tremor.
Who should consider this trial
Good fit: Ideal candidates include patients diagnosed with Parkinson's disease or cerebellar tremor who have undergone surface EMG recordings.
Not a fit: Patients with other neurological diseases or those who have received specific treatments affecting muscle contractions shortly before the EMG recordings may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve the accuracy of tremor characterization and monitoring in patients with Parkinson's disease.
How similar studies have performed: While the approach of analyzing muscle contractions is established, the specific methodology of this study is novel and has not been extensively tested in similar contexts.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * patient who performed surface EMG recordings of wrist flexor-pronators and extensor-supinators in Laboratories; * diagnosis of Parkinson's disease or cerebellar tremor. Exclusion Criteria: * Botulinium toxin injection in upper limb during a delay of 3 months before surface EMG recordings; * Levodopa drugs administrated during a delay of 12 hours before surface EMG recordings; * Tremor-favour drugs administrated during a delay of 30 days before surface EMG recordings; * Presence of an other neurologic disease or of any disease associated with motor disorders in upper limb.
Where this trial is running
Créteil
- Laboratoire Analyse et Restauration du Mouvement — Créteil, France (Recruiting)
Study contacts
- Principal investigator: Emilie Hutin — Henri Mondor University Hospital
- Study coordinator: Emilie Hutin, PhD
- Email: emilie.hutin@aphp.fr
- Phone: +33149812549
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.