Analyzing molecular markers of fibrosis in endometriosis to predict disease severity
Official title: Molecular Markes of Fibrosis of Single Types of Endometriosis and Their Use in Predicting Disease Severity
Run by General University Hospital, Prague · NCT06020482 · Data updated 2026-11-12
This study is trying to see if certain genes in different types of endometriosis can help predict how severe the disease is and how it affects pain and fertility.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 45 Years |
| Sex | Women only |
| Enrollment | 120 (estimated) |
| Sponsor | General University Hospital, Prague Academic / other |
| Locations | 1 site (Prague) |
| Status | Recruiting |
| Started | April 1, 2023 |
| Main results expected | December 31, 2025 |
| Study ends | December 31, 2026 |
| Registry record updated | August 31, 2023 |
| Trial ID | NCT06020482 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are women aged 18-45 with laparoscopically and histologically confirmed endometriosis or those undergoing elective procedures for other benign indications.
✕Probably not a fit
Patients who are older than 45 years or younger than 18 years, or those currently receiving hormonal treatment, may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This project aims to analyze gene expression in different types of ectopic endometrium, including ovarian, peritoneal, and deep infiltrating endometriosis, and compare it with gene expression in normal endometrium. The study focuses on identifying genes with significantly increased expression in each type of ectopic endometrium and correlating these findings with disease severity, ovarian reserve, and clinical manifestations such as pain and infertility. By understanding these molecular markers, the research seeks to enhance the diagnostic utility and treatment strategies for endometriosis.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic tools and personalized treatment options for women suffering from endometriosis.
How similar studies have gone: While previous studies have identified proteins associated with endometriosis, this approach focusing on molecular markers specific to different types of ectopic endometrium is relatively novel and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * women (18-45 years) * signed informed consent with the study * absence of hormonal treatment 3 months before the planned procedure Inclusion criteria for group A: \- laparoscopically and histologically confirmed endometriosis dg. Inclusion criteria for group B: * patients without endometriosis * patients who are undergoing an elective laparoscopic or hysteroscopic procedure in our department for another benign indication * patients with excluded malignant disease Exclusion Criteria: * absence of informed consent * patients who do not meet the inclusion criteria during surgery * patient younger than 18 years of age or older than 45 years of age
Where it's running
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General University Hospital in Prague
Prague, Czechia Recruiting
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.