Analyzing liver injury during surgery
Research on the Molecular Mechanisms of Liver Ischemia-reperfusion Injury and Clinical Data Analysis: an Observational Study
This study looks at how liver injuries happen during surgery to see if new ways can be found to diagnose and treat them better.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 270 (estimated) |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Sponsor | Tongji Hospital Academic / other |
| Locations | 1 site (Wuhan, Hubei) |
| Trial ID | NCT06080308 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on identifying new targets for diagnosing and treating liver ischemia-reperfusion injury. It involves analyzing serological data collected during elective liver resection surgeries that include hepatic pedicle occlusion and subsequent reperfusion. By examining patient-related data alongside these serological analyses, the study aims to uncover key factors that influence reperfusion injury and understand their underlying mechanisms.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 to 70 who are undergoing elective liver resection surgery with hepatic pedicle occlusion.
Not a fit: Patients with end-stage liver disease, severe comorbidities, or those who experience adverse events during surgery may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic and treatment strategies for patients suffering from liver ischemia-reperfusion injury.
How similar studies have performed: While this approach is focused on observational data analysis, similar studies have shown promise in identifying mechanisms of liver injury, suggesting potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Willingness to participate in the study and has signed an informed consent form. 2) Age ≥ 18 years and ≤ 70 years. 3) ASA classification ≤ III. 4) Criteria for liver ischemia-reperfusion injury patients: patients undergoing elective liver resection surgery with hepatic pedicle occlusion and reperfusion during the procedure. Exclusion Criteria: 1) Patients with adverse events during surgery. 2) Patients in the end stage of disease with liver failure. 3) Liver tumor metastasis with concomitant severe heart failure or chronic renal insufficiency, etc. 4) Deemed unsuitable for participation in the study based on the judgment of the researchers. -
Where this trial is running
Wuhan, Hubei
- Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology — Wuhan, Hubei, China (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.