Analyzing limb microfluidics for diagnosing compartment syndrome
Chemical Analysis of Limb Microfluidics
This study is testing a new way to check for compartment syndrome in adults by looking at the chemicals in their limb fluids to see if it can help decide when surgery is really needed.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 12 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Imperial College London Academic / other |
| Locations | 1 site (London) |
| Trial ID | NCT06050499 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on the chemical analysis of limb microfluidics to improve the diagnosis and management of compartment syndrome, a condition characterized by increased pressure in a muscle compartment that can lead to tissue damage. By utilizing a microdialysis catheter and biosensor, the study aims to gather data on blood flow and tissue health in patients at risk of developing this condition. The goal is to better understand when surgical intervention is necessary, potentially reducing unnecessary surgeries and associated risks. The study will involve adult patients undergoing procedures that affect blood flow to the limb.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older who are undergoing procedures that may lead to compartment syndrome or are at risk due to trauma.
Not a fit: Patients under 18 years old or those unable to provide informed consent will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more accurate diagnoses and timely interventions for patients with compartment syndrome, minimizing the risk of permanent tissue damage.
How similar studies have performed: While the approach of using microfluidics for diagnosis is innovative, similar studies have shown promise in improving diagnostic accuracy for other conditions, suggesting potential for success in this area.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Adult patients (aged greater than or equal to 18 years) who are either: i. Undergoing an intervention where there is a controlled reduction in blood flow to the limb that is reversible (e.g. using a tourniquet or clamp) or irreversible (e.g. during limb amputation). ii. At risk of developing compartment syndrome following trauma or surgical intervention as determined by the clinical care team. Exclusion Criteria: Age \<18 years old Unable to provide informed consent
Where this trial is running
London
- Imperial College London — London, United Kingdom (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.