Analyzing immune responses to COVID-2019 vaccination using single-cell techniques

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to recruit healthy adults aged 18 to 50 to analyze the immune response to COVID-2019 vaccination through advanced single-cell multi-omics techniques. By utilizing single-cell RNA sequencing, the study will classify peripheral blood mononuclear cells (PBMCs) to gain insights into immune cell heterogeneity and functionality. The research focuses on understanding the variations in immune cell populations and their potential implications for disease-related research. The findings could enhance our understanding of the immune system's response to vaccination.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1\. Age from 18 to 50 years; 2. No history of major diseases, no history of bacterial or viral infection in the past 3 months; 3. No recent history of surgery or trauma; 4 No history of smoking or alcoholism; 5. No immune system disease.

Exclusion Criteria:

1\. Infectious diseases; 2. Tumor diseases; 3. Hematological diseases; 4. History of hypertension and diabetes; 5 Autoimmune diseases; 6 History of liver and kidney insufficiency; 7. History of previous cardiovascular diseases; 8. Pregnancy Or breast-feeding; 9. Past and current use of immunosuppressive drugs

Where it's running

• Cardiology, Ren Ji Hospital
  Shanghai, China Recruiting

Study contacts

• Principal investigator: Jun Pu, MD,PhD — Cardiology, Ren Ji Hospital Shanghai, China
• Study coordinator: Jun Pu, MD,PhD
• Email: pujun310@hotmail.com
• Phone: 86-21-68383477

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.