Analyzing immune responses in different stages of jaw bone disease related to medication
Characterization of Immunological Parameters in Different Clinical Stages of Medication-Related Osteonecrosis of the Jaw
This study looks at how the immune system reacts at different stages of jaw bone disease caused by medication to see if it can help improve diagnosis and treatment for patients.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 42 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Marmara University Academic / other |
| Locations | 1 site (Istanbul) |
| Trial ID | NCT06420284 on ClinicalTrials.gov |
What this trial studies
This observational study aims to analyze the immunological response profiles at various clinical stages of medication-related osteonecrosis of the jaw (MRONJ). Researchers will assess cytokine levels, inflammation markers, and other immunological parameters to understand their influence on the pathogenesis, staging, and treatment of MRONJ. By examining these stage-specific immunological variables, the study seeks to provide insights that could enhance diagnosis and treatment strategies for patients with MRONJ.
Who should consider this trial
Good fit: Ideal candidates include individuals aged 18 and over who present with medication-related osteonecrosis of the jaw at the Oral and Maxillofacial Surgery Clinic.
Not a fit: Patients with non-drug-related osteonecrosis, osteoradionecrosis, or metastasis to the oral region may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic and treatment approaches for patients suffering from medication-related osteonecrosis of the jaw.
How similar studies have performed: While this study focuses on a specific aspect of MRONJ, similar studies analyzing immunological responses in other conditions have shown promising results, indicating potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Individuals aged 18 and over * Both male and female participants * Individuals who apply to the Oral and Maxillofacial Surgery Clinic at Marmara University Faculty of Dentistry due to medication-related osteonecrosis of the jaw during the study period * Individuals or their legal representatives who have provided written consent to participate in the study Exclusion Criteria: * Non-drug-related osteonecrosis/osteomyelitis * Osteoradionecrosis * Metastasis to the oral region * Individuals who have not given written consent to participate in the study
Where this trial is running
Istanbul
- Marmara University School of Dentistry — Istanbul, Turkey (Türkiye) (Recruiting)
Study contacts
- Study coordinator: Ferit Bayram, PhD
- Email: ferit.bayram@marmara.edu.tr
- Phone: 00902167775000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.