Analyzing immune responses after stem cell transplantation
Determination of Factors Involved in the Regulation of Immune Responses After Allogeneic Hematopoietic Stem Cell Transplantation
NA · Central Hospital, Nancy, France · NCT03357172
This study is trying to understand how the immune system reacts in patients and donors after stem cell transplants to see how it affects recovery and the risk of complications like infections and graft-versus-host disease.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 700 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Central Hospital, Nancy, France (other) |
| Locations | 1 site (Vandœuvre-lès-Nancy) |
| Trial ID | NCT03357172 on ClinicalTrials.gov |
What this trial studies
This study investigates the immune responses of patients and donors involved in allogeneic hematopoietic stem cell transplantation. It aims to analyze the content of immune effector T cells and immunoregulatory cell subtypes in the stem cell graft and correlate these findings with post-transplant immune reconstitution and clinical outcomes such as graft-versus-host disease and infections. Additionally, the study will explore the effects of microbiota dysbiosis on the immune response following transplantation.
Who should consider this trial
Good fit: Ideal candidates include patients scheduled for allogeneic hematopoietic stem cell transplantation at the Nancy CHRU and their corresponding donors.
Not a fit: Patients with positive HIV or active hepatitis B or C infections may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance our understanding of immune recovery post-transplantation, potentially leading to improved patient outcomes.
How similar studies have performed: Other studies have shown promise in understanding immune responses in similar contexts, suggesting that this approach may yield valuable insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * patient of the Nancy CHRU, for whom a CSH allograft is planned. or * hematopoietic stem cell donors received at Nancy's CHRU for the duration of the research Exclusion Criteria: * Positive HIV * active hepatitis B or C infection
Where this trial is running
Vandœuvre-lès-Nancy
- CHRU de Nancy — Vandœuvre-lès-Nancy, France (RECRUITING)
Study contacts
- Study coordinator: Marie-Thérèse RUBIO, PU-PH
- Email: m.rubio@chru-nancy.fr
- Phone: 0383153257
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Allogeneic Hematopoietic Stem Cell Transplantation, Immune recovery, Immunomodulatory cells, GVHD, GVL